NK3 Receptors

The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1068 Senktide
Tachykinin NK3 agonist

Antagonists

Cat No Product Name / Activity
1376 SB 218795
Potent, selective non-peptide NK3 antagonist
1393 SB 222200
Potent, selective non-peptide NK3 antagonist. Brain penetrant
4672 SB 223412
Potent, selective non-peptide NK3 antagonist. Brain penetrant
3297 SSR 146977 hydrochloride
Potent and selective NK3 antagonist

The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord) with limited expression in the periphery.

NK3 receptors are thought to mediate afferent neuron transmission and intestinal motility and secretion. The receptor displays greater potency for the endogenous agonist neurokinin B than neurokinin A and substance P (NKB > NKA > SP). The human gene encoding the NK3 receptor has been localized on chromosome 4 (4q25).

External sources of pharmacological information for NK3 Receptors :

Literature for NK3 Receptors

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NK3 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human TACR3 NM_001059 P29371
Mouse Tacr3 NM_021382 P47937
Rat Tacr3 NM_001059 P29371