Home / Pharmacology / GPCRs / 7-TM Receptors / Peptide Receptors / Tachykinin Receptors / NK3 Receptors

NK3 Receptors

The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).

Products
Background
Literature (6)
Gene Data

NK3 Receptor Agonists
Cat. No. Product Name / Activity
1068 Senktide
Tachykinin NK3 agonist

NK3 Receptor Antagonists
Cat. No. Product Name / Activity
1393 SB 222200
Potent, selective non-peptide NK3 antagonist. Brain penetrant
3297 SSR 146977 hydrochloride
Potent and selective NK3 antagonist

Related Targets

The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord) with limited expression in the periphery.

NK3 receptors are thought to mediate afferent neuron transmission and intestinal motility and secretion. The receptor displays greater potency for the endogenous agonist neurokinin B than neurokinin A and substance P (NKB > NKA > SP). The human gene encoding the NK3 receptor has been localized on chromosome 4 (4q25).

External sources of pharmacological information for NK3 Receptors :

Literature for NK3 Receptors

Tocris offers the following scientific literature for NK3 Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Schizophrenia Poster

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

NK3 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human TACR3 NM_001059 P29371
Mouse Tacr3 NM_021382 P47937
Rat Tacr3 NM_001059 P29371