Hemokinin 1 (human)

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Cat.No. 2576 - Hemokinin 1 (human) | Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2 | CAS No. 491851-53-7
Description: Endogenous, selective NK1 agonist
Datasheet
Citations

Biological Activity

Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.

Technical Data

M. Wt 1185.4
Formula C54H84N14O14S
Sequence TGKASQFFGLM

(Modifications: Met- 11= C-terminal amide)

Storage Desiccate at -20°C
CAS Number 491851-53-7
PubChem ID 71311766
InChI Key NYBLUYYRUFKGTB-XJCFQSCISA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.70 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1185.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.84 mL 4.22 mL 8.44 mL
5 mM 0.17 mL 0.84 mL 1.69 mL
10 mM 0.08 mL 0.42 mL 0.84 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503

Kurtz et al (2002) Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 296 205 PMID: 12383518

Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nature Immunol. 1 392 PMID:


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Keywords: Endogenous selective NK1 agonists Tachykinin Receptors Neurokinin Hemokinin1 (human) NK1 Receptor Peptide

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