Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
(Modifications: Met- 11= C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.70 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1185.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.84 mL||4.22 mL||8.44 mL|
|5 mM||0.17 mL||0.84 mL||1.69 mL|
|10 mM||0.08 mL||0.42 mL||0.84 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References are publications that support the biological activity of the product.
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503
Kurtz et al (2002) Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 296 205 PMID: 12383518
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nature Immunol. 1 392
If you know of a relevant reference for Hemokinin 1 (human), please let us know.
View Related Products by Product Action
Keywords: Hemokinin 1 (human), Hemokinin 1 (human) supplier, Endogenous, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (human), Receptor, 2576, Tocris Bioscience
Citations for Hemokinin 1 (human)
Citations are publications that use Tocris products.
Currently there are no citations for Hemokinin 1 (human). Do you know of a great paper that uses Hemokinin 1 (human) from Tocris? Please let us know.
Reviews for Hemokinin 1 (human)
There are currently no reviews for this product. Be the first to review Hemokinin 1 (human) and earn rewards!
Have you used Hemokinin 1 (human)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.