L-732,138

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Cat.No. 0868 - L-732,138 | C22H18F6N2O3 | CAS No. 148451-96-1
Description: Potent, selective NK1 antagonist
Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Compound Libraries

L-732,138 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 472.39
Formula C22H18F6N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 148451-96-1
PubChem ID 44396853
InChI Key BYYQYXVAWXAYQC-LJQANCHMSA-N
Smiles O=C(N[C@@](CC2=CNC3=C2C=CC=C3)([H])C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 47.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 472.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.17 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cascieri et al (1994) Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 269 6587 PMID: 7509807

Kuo et al (1998) Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 125 711 PMID: 9831906

MacLeod et al (1993) N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 36 2044 PMID: 8393115

MacLeod et al (1994) Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J.Med.Chem. 37 1269 PMID: 7513763


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Keywords: Potent selective NK1 antagonists Tachykinin Receptors Neurokinin L732138 merck NK1 Receptor

1 Citation for L-732,138

Citations are publications that use Tocris products. Selected citations for L-732,138 include:

Li et al (2013) Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. J Neurosci 11 294 PMID: 23345604


Do you know of a great paper that uses L-732,138 from Tocris? If so please let us know.

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