Endogenous tachykinin agonist peptide that shows preference for the NK3 receptor (EC50 = 1 nM).
(Modifications: Met-10 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.80 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1210.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.83 mL||4.13 mL||8.26 mL|
|5 mM||0.17 mL||0.83 mL||1.65 mL|
|10 mM||0.08 mL||0.41 mL||0.83 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References are publications that support the products' biological activity.
Laufer et al (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc.Natl.Acad.Sci.U.S.A. 82 7444 PMID: 2414777
Severini et al (2002) The tachykinin peptide family. Pharmacol.Rev. 54 285 PMID: 12037144
Wang et al (2001) Neurokinin B potentiates ATP-activated currents in rat DRG neurons. Brain Res. 923 157 PMID: 11743983
If you know of a relevant reference for Neurokinin B (human, porcine), please let us know.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.