Neurokinin B (human, porcine)

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Cat.No. 1582 - Neurokinin B (human, porcine) | Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 | CAS No. 86933-75-7
Description: Endogenous tachykinin peptide
Alternative Names: NKB
Datasheet
Citations
Literature

Biological Activity

Endogenous tachykinin agonist peptide that shows preference for the NK3 receptor (EC50 = 1 nM).

Technical Data

M. Wt 1210.43
Formula C55H79N13O14S2
Sequence DMHDFFVGLM

(Modifications: Met-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 86933-75-7
PubChem ID 5311312
InChI Key NHXYSAFTNPANFK-HDMCBQFHSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.80 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1210.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.13 mL 8.26 mL
5 mM 0.17 mL 0.83 mL 1.65 mL
10 mM 0.08 mL 0.41 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Laufer et al (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc.Natl.Acad.Sci.U.S.A. 82 7444 PMID: 2414777

Severini et al (2002) The tachykinin peptide family. Pharmacol.Rev. 54 285 PMID: 12037144

Wang et al (2001) Neurokinin B potentiates ATP-activated currents in rat DRG neurons. Brain Res. 923 157 PMID: 11743983


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Citations for Neurokinin B (human, porcine)

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Pathways for Neurokinin B (human, porcine)

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