NK2 Receptors

The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (including inflammatory cells and bronchial smooth muscle).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1668 GR 64349
Potent, selective NK2 agonist
1640 [bAla8]-Neurokinin A(4-10)
NK2 agonist
3228 [Lys5,MeLeu9,Nle10]-NKA(4-10)
Selective NK2 agonist

Antagonists

Cat No Product Name / Activity
1274 GR 159897
Non-peptide, potent NK2 antagonist
1667 GR 94800
Potent, selective NK2 antagonist
1194 MDL 29,913
Selective NK2 antagonist
1632 MEN 10376
Potent, selective NK2 antagonist

The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle) with limited expression in the CNS.

NK2 receptors are thought to mediate mood control, gastrointestinal contraction and airway and lung function. The receptor displays greater potency for the endogenous agonist neurokinin A than neurokinin B and substance P (NKA > NKB > SP). The human gene encoding the NK2 receptor has been localized on chromosome 10 (10pter-q23).

External sources of pharmacological information for NK2 Receptors :

Literature for NK2 Receptors

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

NK2 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human TACR2 NM_001057 P21452
Mouse Tacr2 NM_009314 P30549
Rat Tacr2 NM_080768 P16610