NK2 Receptors

The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (including inflammatory cells and bronchial smooth muscle).

Products
Background
Literature (6)
Gene Data

NK2 Receptor Agonists

Cat. No. Product Name / Activity
1668 GR 64349
Potent, selective NK2 agonist

NK2 Receptor Antagonists

Cat. No. Product Name / Activity
1274 GR 159897
Non-peptide, potent NK2 antagonist

The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle) with limited expression in the CNS.

NK2 receptors are thought to mediate mood control, gastrointestinal contraction and airway and lung function. The receptor displays greater potency for the endogenous agonist neurokinin A than neurokinin B and substance P (NKA > NKB > SP). The human gene encoding the NK2 receptor has been localized on chromosome 10 (10pter-q23).

External sources of pharmacological information for NK2 Receptors :

Literature for NK2 Receptors

Tocris offers the following scientific literature for NK2 Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Peptides Involved in Appetite Modulation Scientific Review

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Cardiovascular Poster

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Depression Poster

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

NK2 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human TACR2 NM_001057 P21452
Mouse Tacr2 NM_009314 P30549
Rat Tacr2 NM_080768 P16610