[Lys5,MeLeu9,Nle10]-NKA(4-10)

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Cat.No. 3228 - [Lys5,MeLeu9,Nle10]-NKA(4-10) | Asp-Lys-Phe-Val-Gly-Leu(N-methyl)-Nle-NH2 | CAS No. 137565-28-7
Description: Selective NK2 agonist
Datasheet
Citations

Biological Activity

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Technical Data

M. Wt 804
Formula C39H65N9O9
Sequence DKFVGLX

(Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide)

Storage Desiccate at -20°C
CAS Number 137565-28-7
PubChem ID 10417908
InChI Key FIBMQAYBIOYAKI-HLYNNXGTSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.22 mL 12.44 mL
5 mM 0.25 mL 1.24 mL 2.49 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chassaing et al (1991) Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 19 91 PMID: 1658676

Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274

Burcher et al (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 324 170 PMID: 17959748


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Keywords: Selective NK2 agonists Tachykinin Receptors Neurokinin NK2 Receptor Peptide

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