Pricing Availability   Qty
Cat.No. 3228 - [Lys5,MeLeu9,Nle10]-NKA(4-10) | Asp-Lys-Phe-Val-Gly-Leu(N-methyl)-Nle-NH2 | CAS No. 137565-28-7
Description: Selective NK2 agonist
Literature (6)

Biological Activity

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Technical Data

M. Wt 804
Formula C39H65N9O9
Sequence DKFVGLX

(Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide)

Storage Desiccate at -20°C
CAS Number 137565-28-7
PubChem ID 10417908
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Chassaing et al (1991) Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 19 91 PMID: 1658676

Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274

Burcher et al (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomet. and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 324 170 PMID: 17959748

If you know of a relevant reference for [Lys5,MeLeu9,Nle10]-NKA(4-10), please let us know.

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Keywords: [Lys5,MeLeu9,Nle10]-NKA(4-10), [Lys5,MeLeu9,Nle10]-NKA(4-10) supplier, Selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, Receptor, 3228, Tocris Bioscience

Citations for [Lys5,MeLeu9,Nle10]-NKA(4-10)

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