Senktide

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Cat.No. 1068 - Senktide | Succinyl-Asp-Phe-Me-Phe-Gly-Leu-Met-NH2 | CAS No. 106128-89-6
Description: Tachykinin NK3 agonist
Datasheet
Citations (5)

Biological Activity

NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

Technical Data

M. Wt 841.97
Formula C40H55N7O11S
Sequence DFFGLM

(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 106128-89-6
PubChem ID 90479751
InChI Key UGXWLDUHYDFTIA-QKUYTOGTSA-N
Smiles CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=C(C)C=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in PBS (pH 7.4)

Preparing Stock Solutions

The following data is based on the product molecular weight 841.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.19 mL 5.94 mL 11.88 mL
5 mM 0.24 mL 1.19 mL 2.38 mL
10 mM 0.12 mL 0.59 mL 1.19 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3 PMID: 1375857

Nordquist et al (2008) The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87 PMID: 18930726

Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide. Neuropeptides 18 107 PMID: 1712430


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Keywords: Tachykinin NK3 agonists Receptors Neurokinin NK3 Receptor

5 Citations for Senktide

Citations are publications that use Tocris products. Selected citations for Senktide include:

Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Cereb Cortex 7 e44344 PMID: 23028524

Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. J Neurosci 16 1440 PMID: 16339088

Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. Sci Rep 24 10103 PMID: 15537880

León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206 PMID: 26755241

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Nat Commun 156 627 PMID: 25422875


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