Senktide

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Description: Tachykinin NK3 agonist
Purity: ≥95% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (6)

Biological Activity for Senktide

Senktide is a NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

Technical Data for Senktide

M. Wt 841.97
Formula C40H55N7O11S
Sequence DFFGLM

(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 106128-89-6
PubChem ID 90479751
InChI Key UGXWLDUHYDFTIA-QKUYTOGTSA-N
Smiles CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=C(C)C=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Senktide

Solubility Soluble to 1 mg/ml in PBS (pH 7.4)

Product Datasheets for Senktide

Certificate of Analysis / Product Datasheet
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References for Senktide

References are publications that support the biological activity of the product.

Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of DA-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3 PMID: 1375857

Nordquist et al (2008) The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87 PMID: 18930726

Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide. Neuropeptides 18 107 PMID: 1712430


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Keywords: Senktide, Senktide supplier, Tachykinin, NK3, agonists, Receptors, Neurokinin, Receptor, 1068, Tocris Bioscience

8 Citations for Senktide

Citations are publications that use Tocris products. Selected citations for Senktide include:

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Nat Commun 156 627 PMID: 25422875

Glidewell-Kenney et al (2013) Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol 27 437 PMID: 23393128

Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons. Sci Rep 24 10103 PMID: 15537880

León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206 PMID: 26755241


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Reviews for Senktide

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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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