NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.
(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in PBS (pH 7.4)|
Preparing Stock Solutions
The following data is based on the product molecular weight 841.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.19 mL||5.94 mL||11.88 mL|
|5 mM||0.24 mL||1.19 mL||2.38 mL|
|10 mM||0.12 mL||0.59 mL||1.19 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
References are publications that support the biological activity of the product.
Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3 PMID: 1375857
Nordquist et al (2008) The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87 PMID: 18930726
Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide. Neuropeptides 18 107 PMID: 1712430
If you know of a relevant reference for Senktide, please let us know.
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Keywords: Senktide, Senktide supplier, Tachykinin, NK3, agonists, Receptors, Neurokinin, Receptor, 1068, Tocris Bioscience
5 Citations for Senktide
Citations are publications that use Tocris products. Selected citations for Senktide include:
Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. J Neurosci 16 1440 PMID: 16339088
Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Cereb Cortex 7 e44344 PMID: 23028524
León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206 PMID: 26755241
Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. Sci Rep 24 10103 PMID: 15537880
Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Nat Commun 156 627 PMID: 25422875
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.