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Description: Tachykinin NK3 agonist
Purity: ≥95% (HPLC)
Citations (8)
Literature (6)

Biological Activity for Senktide

Senktide is a NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

Technical Data for Senktide

M. Wt 841.97
Formula C40H55N7O11S
Sequence DFFGLM

(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 106128-89-6
PubChem ID 90479751
Smiles CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=C(C)C=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Senktide

Solubility Soluble to 1 mg/ml in PBS (pH 7.4)

Product Datasheets for Senktide

Certificate of Analysis / Product Datasheet
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References for Senktide

References are publications that support the biological activity of the product.

Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of DA-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3 PMID: 1375857

Nordquist et al (2008) The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87 PMID: 18930726

Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide. Neuropeptides 18 107 PMID: 1712430

If you know of a relevant reference for Senktide, please let us know.

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Keywords: Senktide, Senktide supplier, Tachykinin, NK3, agonists, Receptors, Neurokinin, Receptor, 1068, Tocris Bioscience

8 Citations for Senktide

Citations are publications that use Tocris products. Selected citations for Senktide include:

Zelikowsky et al (2018) The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell 173 1265 PMID: 29775595

Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. J Neurosci 16 1440 PMID: 16339088

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Nat Commun 156 627 PMID: 25422875

Glidewell-Kenney et al (2013) Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol 27 437 PMID: 23393128

Do you know of a great paper that uses Senktide from Tocris? Please let us know.

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Literature in this Area

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