Substance P

Pricing Availability   Qty
Description: Sensory neuropeptide; inflammatory mediator
Purity: ≥95% (HPLC)
Citations (15)
Literature (1)

Biological Activity for Substance P

Substance P is a sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.

Technical Data for Substance P

M. Wt 1347.6
Formula C63H98N18O13S

(Modifications: Met-11 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 33507-63-0
PubChem ID 36511
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Substance P

Solubility Soluble to 0.80 mg/ml in water

Product Datasheets for Substance P

Certificate of Analysis / Product Datasheet
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References for Substance P

References are publications that support the biological activity of the product.

Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID: 9732370

Pernow et al (1983) Substance P. Pharmacol.Rev. 35 85 PMID: 6196797

Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID: 7541689

Merck Index 12 9032

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Keywords: Substance P, Substance P supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Other, 1156, Tocris Bioscience

15 Citations for Substance P

Citations are publications that use Tocris products. Selected citations for Substance P include:

Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553 PMID: 24381506

Hanson et al (2009) A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through β-arrestin recruitment. Antioxid Redox Signal 14 798 PMID: 19531663

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci 29 15551 PMID: 20007479

Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID: 24310605

Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons. J Biomol Screen 24 10103 PMID: 15537880

Gutierrez and Boada (2019) Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18 216 PMID: 30598641

Wease and Davies (2005) Substance P selectively decreases paired pulse depression in the rat hippocampal slice. BMC Neurosci 6 66 PMID: 16305744

Chen et al (2014) μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience 267 67 PMID: 24583035

Shanley et al (2011) Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones. J Neurosci 8 10 PMID: 21294877

Fisher et al (2015) Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9 37 PMID: 25617052

Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID: 21931717

Kowtharapu et al (2018) Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing. Int J Mol Sci 19 PMID: 29401709

Frara et al (2018) Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes. Connect Tissue Res 59 30 PMID: 28399671

Wan et al (2017) Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci 9 167 PMID: 28119567

Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.