Hemokinin 1 (mouse)

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Cat.No. 1535 - Hemokinin 1 (mouse) | Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2 | CAS No. 208041-90-1
Description: Endogenous, high affinity, selective NK1 agonist
Alternative Names: HK-1, HEK-1
Datasheet
Citations

Biological Activity

Novel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.

Technical Data

M. Wt 1413.66
Formula C61H100N22O15S
Sequence RSRTRQFYGLM

(Modifications: Met-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 208041-90-1
PubChem ID 90479800
InChI Key ZOLDEMZLDJFVRY-RULPZMNSSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1413.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.71 mL 3.54 mL 7.07 mL
5 mM 0.14 mL 0.71 mL 1.41 mL
10 mM 0.07 mL 0.35 mL 0.71 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503

Morteau et al (2001) Hemokinin 1 is a full agonist at the substance P receptor. Nat.Immunol. 2 1088 PMID: 11725292

Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat.Immunol. 1 392 PMID: 11062498


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Keywords: Endogenous high affinity selective NK1 agonists Tachykinin Receptors Neurokinin Hemokinin1 (mouse) HK-1 HEK-1 NK1 Receptor Peptide

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