Hemokinin 1 (mouse)
Novel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
(Modifications: Met-11 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503
Morteau et al (2001) Hemokinin 1 is a full agonist at the substance P receptor. Nat.Immunol. 2 1088 PMID: 11725292
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat.Immunol. 1 392 PMID: 11062498
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Keywords: Hemokinin 1 (mouse), Hemokinin 1 (mouse) supplier, Endogenous, high, affinity, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (mouse), HK-1, HEK-1, Receptor, 1535, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.