Neurokinin A (porcine)

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Cat.No. 1152 - Neurokinin A (porcine) | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 | CAS No. 86933-74-6
Description: Endogenous tachykinin peptide
Alternative Names: NKA
Datasheet
Citations

Biological Activity

Endogenous tachykinin peptide; more potent bronchoconstrictor than Substance P.

Technical Data

M. Wt 1133.3
Formula C50H80N14O14S
Sequence HKTDSFVGLM

(Modifications: Met-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 86933-74-6
PubChem ID 5311311
InChI Key HEAUFJZALFKPBA-JPQUDPSNSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1133.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.88 mL 4.41 mL 8.82 mL
5 mM 0.18 mL 0.88 mL 1.76 mL
10 mM 0.09 mL 0.44 mL 0.88 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lippe et al (1997) Neurokinin A-induced vasoconstriction and muscular contraction in the rat isolated stomach: mediation by distinct and unusual neurokinin A2 receptors. J.Pharmacol.Exp.Ther. 281 1294 PMID: 9190865

Nawa et al (1983) Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306 32 PMID: 6195531

Sherwood et al (1997) Bronchoconstrictor and respiratory effects of neurokinin A in dogs. J.Pharmacol.Exp.Ther. 283 788 PMID: 9353399


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Keywords: Endogenous tachykinin peptide Non-Selective Neurokinin Receptors agonists NeurokininA NKA Other Tachykinin

Citations for Neurokinin A (porcine)

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