Tachykinin NK1 receptor antagonist.
Sold for research purposes under agreement from GlaxoSmithKline
(Modifications: X-1 = Glp, Leu-10 = spiro-g-lactam-Leu, Trp-11 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1386.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.72 mL||3.61 mL||7.21 mL|
|5 mM||0.14 mL||0.72 mL||1.44 mL|
|10 mM||0.07 mL||0.36 mL||0.72 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
References are publications that support the biological activity of the product.
Guo et al (1995) Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat. Eur.J.Pharmacol. 281 49 PMID: 8566116
Lecci et al (1992) Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 51 PL277 PMID: 1335533
Hagan et al (1991) A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase-resistant, selective neurokinin NK-1 receptor antagonist. Br.J.Pharmacol. 102 168P
If you know of a relevant reference for GR 82334, please let us know.
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Keywords: GR 82334, GR 82334 supplier, Tachykinin, NK1, receptor, antagonists, Receptors, Neurokinin, GR82334, GlaxoSmithKline, GSK, Receptor, 1670, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.