GR 82334

Discontinued Product

GR 82334 (Cat. No. 1670) has been withdrawn from sale for commercial reasons.
Description: NK1 antagonist
Literature (2)

Biological Activity for GR 82334

GR 82334 is a tachykinin NK1 receptor antagonist.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GR 82334

M. Wt 1386.57
Formula C69H91N15O16

(Modifications: X-1 = Glp, Leu-10 = spiro-g-lactam-Leu, Trp-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 129623-01-4
PubChem ID 16130972
Smiles CC(C)C[C@H](N1CC[C@@]2(CCCN2C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]2CCC(=O)N2)C1=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for GR 82334

Certificate of Analysis / Product Datasheet
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References for GR 82334

References are publications that support the biological activity of the product.

Guo et al (1995) Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat. Eur.J.Pharmacol. 281 49 PMID: 8566116

Lecci et al (1992) Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 51 PL277 PMID: 1335533

Hagan et al (1991) A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase-resistant, selective neurokinin NK-1 receptor antagonist. Br.J.Pharmacol. 102 168P

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Keywords: GR 82334, GR 82334 supplier, Tachykinin, NK1, receptor, antagonists, Receptors, Neurokinin, GR82334, GlaxoSmithKline, GSK, Receptor, 1670, Tocris Bioscience

Citations for GR 82334

Citations are publications that use Tocris products.

Currently there are no citations for GR 82334.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.