GR 82334

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Cat.No. 1670 - GR 82334 | Glp-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Pro(spiro-γ-lactam-Leu-Trp-NH2 | CAS No. 129623-01-4
Description: NK1 antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Tachykinin NK1 receptor antagonist.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 1386.57
Formula C69H91N15O16
Sequence XADPNKFYPLW

(Modifications: X-1 = Glp, Leu-10 = spiro-g-lactam-Leu, Trp-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 129623-01-4
PubChem ID 16130972
InChI Key KWECNVXXONDEKG-JTCMYMKESA-N
Smiles CC(C)C[C@H](N1CC[C@@]2(CCCN2C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]2CCC(=O)N2)C1=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Guo et al (1995) Pharmacological characterisation of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat. Eur.J.Pharmacol. 281 49 PMID: 8566116

Lecci et al (1992) Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 51 PL277 PMID: 1335533

Hagan et al (1991) A spirolactam conformationally-constrained analogue of physalaemin which is a peptidase-resistant, selective neurokinin NK-1 receptor antagonist. Br.J.Pharmacol. 102 168P


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Keywords: GR 82334, GR 82334 supplier, Tachykinin, NK1, receptor, antagonists, Receptors, Neurokinin, GR82334, GlaxoSmithKline, GSK, Receptor, 1670, Tocris Bioscience

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