Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.
Inhibitors |
|
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Cat No | Product Name / Activity |
4128 | Bisindolylmaleimide II |
Potent PKC inhibitor and nicotinic receptor antagonist | |
1626 | Calphostin C |
Potent, selective and photo-dependent PKC inhibitor | |
2442 | CGP 53353 |
Selective inhibitor of PKCβII | |
1330 | Chelerythrine chloride |
Cell-permeable protein kinase C inhibitor | |
5922 | CRT 0066854 hydrochloride |
PKCι and PKCζ inhibitor | |
0749 | Dihydrosphingosine |
Protein kinase C inhibitor | |
5994 | Enzastaurin |
Potent PKCβ inhibitor | |
0741 | GF 109203X |
Protein kinase C inhibitor | |
2253 | Go 6976 |
Potent protein kinase C inhibitor; selective for α and β isozymes | |
2285 | Go 6983 |
Broad spectrum PKC inhibitor | |
2287 | K-252c |
Protein kinase C inhibitor | |
4738 | LY 333531 hydrochloride |
Protein kinase C inhibitor; selective for β isozymes | |
1900 | [Ala107]-MBP (104-118) |
Protein kinase C inhibitor | |
1901 | [Ala113]-MBP (104-118) |
Protein kinase C inhibitor | |
1193 | Melittin |
Inhibits protein kinase C and cAMP-dependent protein kinase | |
0609 | (±)-Palmitoylcarnitine chloride |
Protein kinase C inhibitor | |
4058 | PKC (19-36) |
Pseudosubstrate peptide; inhibitor of PKC | |
2992 | PKC 412 |
Protein kinase C inhibitor | |
1792 | PKC β pseudosubstrate |
Selective cell-permeable PKC inhibitor peptide (attached to vector) | |
1791 | PKC ζ pseudosubstrate |
PKC ζ inhibitor peptide (attached to cell-permeable vector) | |
1587 | Ro 32-0432 hydrochloride |
Potent, orally active PKC inhibitor | |
1610 | Rottlerin |
Reported PKCδ inhibitor | |
0633 | D-erythro-Sphingosine (synthetic) |
Protein kinase C inhibitor | |
4221 | TCS 21311 |
PKCα and PKCθ inhibitor. Also inhibits JAK3 | |
2549 | ZIP |
Cell-permeable inhibitor of atypical PKC isozyme PKMζ | |
3215 | ZIP (Scrambled) |
Control peptide for ZIP (Cat. No. 2549) | |
3290 | ZIP, Biotinylated |
Biotinylated peptide for ZIP (Cat. No. 2549) | |
Activators |
|
Cat No | Product Name / Activity |
2383 | Bryostatin 1 |
Protein kinase C activator | |
5237 | Bryostatin 2 |
Protein kinase C activator | |
5238 | Bryostatin 3 |
Potent protein kinase C activator | |
3091 | FR 236924 |
Selective PKCε activator | |
4054 | PEP 005 |
Protein kinase C activator | |
4153 | Phorbol 12,13-dibutyrate |
Protein kinase C activator | |
1201 | Phorbol 12-myristate 13-acetate |
Protein kinase C activator | |
5739 | Prostratin |
PKC activator; also NF-κB activator | |
1790 | Pseudo RACK1 |
Protein kinase C activator peptide (attached to cell permeable vector) | |
0433 | SC-9 |
Protein kinase C activator | |
5343 | TPPB |
High affinity PKC activator; also APP modulator | |
Other |
|
Cat No | Product Name / Activity |
3427 | Oncrasin 1 |
Induces abnormal nuclear aggregation of PKCι; proapoptotic |
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs ε-, δ-, θ- and η- isotypes) are also activated by DAG and phosphatidylserine.
The atypical PKCs (aPKCs ι- and ζ-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region.
The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.
Tocris offers the following scientific literature for Protein Kinase C to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
cPKCα | Human | PRKCA | NM_002737 | P17252 |
Mouse | Prkca | NM_011101 | P20444 | |
Rat | Prkca | NM_001105713 | P05696 | |
cPKCβI | Human | PRKCB | NM_212535 | P05771 |
Mouse | Prkcb | NM_008855 | P68404 | |
Rat | Prkcb | NM_012713 | P68403 | |
cPKCγ | Human | PRKCG | NM_002739 | P05129 |
Mouse | Prkcc | NM_011102 | P63318 | |
Rat | Prkcc | NM_012628 | P63319 | |
nPKCδ | Human | PRKCD | NM_006254 | Q05655 |
Mouse | Prkcd | NM_011103 | P28867 | |
Rat | Prkcd | NM_133307 | P09215 | |
nPKCε | Human | PRKCE | NM_005400 | Q02156 |
Mouse | Prkce | NM_011104 | P16054 | |
Rat | Prkce | NM_017171 | P09216 | |
nPKCθ | Human | PRKCQ | NM_006257 | Q04759 |
Mouse | Prkcq | NM_008859 | Q02111 | |
nPKCη | Human | PRKCH | NM_006255 | P24723 |
Mouse | Prkch | NM_008856 | P23298 | |
Rat | Prkch | NM_031085 | Q64617 | |
aPKCι | Human | PRKCI | NM_002740 | P41743 |
Mouse | Prkci | NM_008857 | Q62074 | |
Rat | Prkci | EU517502 | P97701 | |
aPKCζ | Human | PRKCZ | NM_002744 | Q05513 |
Mouse | Prkcz | NM_008860 | Q02956 | |
Rat | Prkcz | NM_022507 | P09217 |