Protein Kinase C

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4128 Bisindolylmaleimide II
Potent PKC inhibitor and nicotinic receptor antagonist
0543 C-1
Protein kinase C inhibitor
1626 Calphostin C
Potent, selective and photo-dependent PKC inhibitor
2442 CGP 53353
Selective inhibitor of PKCβII
1330 Chelerythrine chloride
Cell-permeable protein kinase C inhibitor
0749 Dihydrosphingosine
Protein kinase C inhibitor
5994 Enzastaurin
Potent PKCβ inhibitor
0741 GF 109203X
Protein kinase C inhibitor
2253 Go 6976
Potent protein kinase C inhibitor; selective for α and β isozymes
2285 Go 6983
Broad spectrum PKC inhibitor
2287 K-252c
Protein kinase C inhibitor
4738 LY 333531 hydrochloride
Protein kinase C inhibitor; selective for β isozymes
1900 [Ala107]-MBP (104-118)
Protein kinase C inhibitor
1901 [Ala113]-MBP (104-118)
Protein kinase C inhibitor
1193 Melittin
Inhibits protein kinase C and cAMP-dependent protein kinase
0609 (±)-Palmitoylcarnitine chloride
Protein kinase C inhibitor
4058 PKC (19-36)
Pseudosubstrate peptide; inhibitor of PKC
4059 [Glu27]-PKC (19-36)
Inactive control peptide for PKC (19-36) (Cat. No. 4058)
2992 PKC 412
Protein kinase C inhibitor
1792 PKC β pseudosubstrate
Selective cell-permeable PKC inhibitor peptide (attached to vector)
1791 PKC ζ pseudosubstrate
PKC ζ inhibitor peptide (attached to cell-permeable vector)
1587 Ro 32-0432 hydrochloride
Potent, orally active PKC inhibitor
1610 Rottlerin
Reported PKCδ inhibitor
0633 D-erythro-Sphingosine (synthetic)
Protein kinase C inhibitor
4221 TCS 21311
PKCα and PKCθ inhibitor. Also inhibits JAK3
2549 ZIP
Cell-permeable inhibitor of atypical PKC isozyme PKMζ
3215 ZIP (Scrambled)
Control peptide for ZIP (Cat. No. 2549)
3290 ZIP, Biotinylated
Biotinylated peptide for ZIP (Cat. No. 2549)

Activators

Cat No Product Name / Activity
2383 Bryostatin 1
Protein kinase C activator
5237 Bryostatin 2
Protein kinase C activator
5238 Bryostatin 3
Potent protein kinase C activator
3091 FR 236924
Selective PKCε activator
4054 PEP 005
Protein kinase C activator
4153 Phorbol 12,13-dibutyrate
Protein kinase C activator
1201 Phorbol 12-myristate 13-acetate
Protein kinase C activator
5739 Prostratin
PKC activator; also NF-κB activator
1790 Pseudo RACK1
Protein kinase C activator peptide (attached to cell permeable vector)
0433 SC-9
Protein kinase C activator
5343 TPPB
High affinity PKC activator; also APP modulator

Other

Cat No Product Name / Activity
3427 Oncrasin 1
Induces abnormal nuclear aggregation of PKCι; proapoptotic

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs ε-, δ-, θ- and η- isotypes) are also activated by DAG and phosphatidylserine.

The atypical PKCs (aPKCs ι- and ζ-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region.

The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

External sources of pharmacological information for Protein Kinase C :

    Literature for Protein Kinase C

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    Protein Kinase C Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    cPKCα Human PRKCA NM_002737 P17252
    Mouse Prkca NM_011101 P20444
    Rat Prkca NM_001105713 P05696
    cPKCβI Human PRKCB NM_212535 P05771
    Mouse Prkcb NM_008855 P68404
    Rat Prkcb NM_012713 P68403
    cPKCγ Human PRKCG NM_002739 P05129
    Mouse Prkcc NM_011102 P63318
    Rat Prkcc NM_012628 P63319
    nPKCδ Human PRKCD NM_006254 Q05655
    Mouse Prkcd NM_011103 P28867
    Rat Prkcd NM_133307 P09215
    nPKCε Human PRKCE NM_005400 Q02156
    Mouse Prkce NM_011104 P16054
    Rat Prkce NM_017171 P09216
    nPKCθ Human PRKCQ NM_006257 Q04759
    Mouse Prkcq NM_008859 Q02111
    nPKCη Human PRKCH NM_006255 P24723
    Mouse Prkch NM_008856 P23298
    Rat Prkch NM_031085 Q64617
    aPKCι Human PRKCI NM_002740 P41743
    Mouse Prkci NM_008857 Q62074
    Rat Prkci EU517502 P97701
    aPKCζ Human PRKCZ NM_002744 Q05513
    Mouse Prkcz NM_008860 Q02956
    Rat Prkcz NM_022507 P09217