Protein Kinase C

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca²⁺ insensitive novel PKCs (nPKCs ε-, δ-, θ- and η- isotypes) are also activated by DAG and phosphatidylserine.

The atypical PKCs (aPKCs ι- and ζ-) are insensitive to Ca²⁺, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region.

The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

External sources of pharmacological information for Protein Kinase C :

• IUPHAR Receptor Code

• BJP Guide

Literature for Protein Kinase C

Tocris offers the following scientific literature for Protein Kinase C to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

• Cancer Metabolism
• Epigenetics in Cancer
• Receptor Signaling
• Cell Cycle and DNA Damage Repair
• Angiogenesis
• Invasion and Metastasis

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

• Receptor Tyrosine Kinases
• Protein Kinases A, C, D and G
• PI-3 Kinase, Akt and mTOR
• MAPK Signaling
• Receptor Serine/Threonine Kinases

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

• Nociception
• Ion Channels
• G-Protein-Coupled Receptors
• Intracellular Signaling

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• View all Product Guides & Listings

Protein Kinase C Gene Data