Protein Kinase C
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.
Protein Kinase C Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 4128 | Bisindolylmaleimide II |
| Potent PKC inhibitor; also potent nAChR antagonist | |
| 1626 | Calphostin C |
| Potent, selective and photo-dependent PKC inhibitor | |
| 2442 | CGP 53353 |
| Selective inhibitor of PKCβII | |
| 1330 | Chelerythrine chloride |
| Cell-permeable protein kinase C inhibitor | |
| 5922 | CRT 0066854 hydrochloride |
| PKCι and PKCζ inhibitor | |
| 0741 | GF 109203X |
| Protein kinase C inhibitor | |
| 2253 | Go 6976 |
| Potent protein kinase C inhibitor; selective for α and β isozymes | |
| 2285 | Go 6983 |
| Broad spectrum PKC inhibitor | |
| 2287 | K-252c |
| Protein kinase C inhibitor | |
| 1193 | Melittin |
| Inhibits protein kinase C and cAMP-dependent protein kinase | |
| 0609 | (±)-Palmitoylcarnitine chloride |
| Protein kinase C inhibitor | |
| 2992 | PKC 412 |
| Protein kinase C inhibitor | |
| 1791 | PKC ζ pseudosubstrate |
| PKC ζ inhibitor peptide (attached to cell-permeable vector) | |
| 1587 | Ro 32-0432 hydrochloride |
| Potent, orally active PKC inhibitor | |
| 1610 | Rottlerin |
| Reported PKCδ inhibitor | |
| 0633 | D-erythro-Sphingosine (synthetic) |
| Protein kinase C inhibitor | |
| 4221 | TCS 21311 |
| PKCα and PKCθ inhibitor. Also inhibits JAK3 | |
| 2549 | ZIP |
| Cell-permeable inhibitor of atypical PKC isozyme PKMζ | |
| 3215 | ZIP (Scrambled) |
| Control peptide for ZIP (Cat. No. 2549) | |
Protein Kinase C Activators |
|
| Cat. No. | Product Name / Activity |
| 2383 | Bryostatin 1 |
| Protein kinase C activator | |
| 4054 | PEP 005 |
| Protein kinase C activator | |
| 4153 | Phorbol 12,13-dibutyrate |
| Protein kinase C activator | |
| 1201 | Phorbol 12-myristate 13-acetate |
| Protein kinase C activator | |
| 5739 | Prostratin |
| PKC activator; also NF-κB activator | |
| 0433 | SC-9 |
| Protein kinase C activator | |
| 5343 | TPPB |
| High affinity PKC activator; also APP modulator | |
Other |
|
| Cat. No. | Product Name / Activity |
| 3427 | Oncrasin 1 |
| Induces abnormal nuclear aggregation of PKCι; proapoptotic | |
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs ε-, δ-, θ- and η- isotypes) are also activated by DAG and phosphatidylserine.
The atypical PKCs (aPKCs ι- and ζ-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region.
The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.
External sources of pharmacological information for Protein Kinase C :
Literature for Protein Kinase C
Tocris offers the following scientific literature for Protein Kinase C to showcase our products. We invite you to request* your copy today!
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
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Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Protein Kinase C Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| cPKCα | Human | PRKCA | NM_002737 | P17252 |
| Mouse | Prkca | NM_011101 | P20444 | |
| Rat | Prkca | NM_001105713 | P05696 | |
| cPKCβI | Human | PRKCB | NM_212535 | P05771 |
| Mouse | Prkcb | NM_008855 | P68404 | |
| Rat | Prkcb | NM_012713 | P68403 | |
| cPKCγ | Human | PRKCG | NM_002739 | P05129 |
| Mouse | Prkcc | NM_011102 | P63318 | |
| Rat | Prkcc | NM_012628 | P63319 | |
| nPKCδ | Human | PRKCD | NM_006254 | Q05655 |
| Mouse | Prkcd | NM_011103 | P28867 | |
| Rat | Prkcd | NM_133307 | P09215 | |
| nPKCε | Human | PRKCE | NM_005400 | Q02156 |
| Mouse | Prkce | NM_011104 | P16054 | |
| Rat | Prkce | NM_017171 | P09216 | |
| nPKCθ | Human | PRKCQ | NM_006257 | Q04759 |
| Mouse | Prkcq | NM_008859 | Q02111 | |
| nPKCη | Human | PRKCH | NM_006255 | P24723 |
| Mouse | Prkch | NM_008856 | P23298 | |
| Rat | Prkch | NM_031085 | Q64617 | |
| aPKCι | Human | PRKCI | NM_002740 | P41743 |
| Mouse | Prkci | NM_008857 | Q62074 | |
| Rat | Prkci | EU517502 | P97701 | |
| aPKCζ | Human | PRKCZ | NM_002744 | Q05513 |
| Mouse | Prkcz | NM_008860 | Q02956 | |
| Rat | Prkcz | NM_022507 | P09217 |
Our Cancer Research Guide highlights over 750 products for cancer research.
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