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Protein Kinase C

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Products
Background
Literature (3)
Gene Data

Protein Kinase C Antagonists
Cat. No. Product Name / Activity
7962 TAT-SAMβA Peptide
Selective antagonist of Mfn1-βIIPKC association

Protein Kinase C Inhibitors
Cat. No. Product Name / Activity
4128 Bisindolylmaleimide II
Potent PKC inhibitor; also potent nAChR antagonist
1626 Calphostin C
Potent, selective and photo-dependent PKC inhibitor
2442 CGP 53353
Selective inhibitor of PKCβII
1330 Chelerythrine chloride
Cell-permeable protein kinase C inhibitor
5922 CRT 0066854 hydrochloride
PKCι and PKCζ inhibitor
0741 GF 109203X
Protein kinase C inhibitor
2253 Go 6976
Potent protein kinase C inhibitor; selective for α and β isozymes
2285 Go 6983
Broad spectrum PKC inhibitor
1193 Melittin
Inhibits protein kinase C and cAMP-dependent protein kinase
2992 PKC 412
Protein kinase C inhibitor
1587 Ro 32-0432 hydrochloride
Potent, orally active PKC inhibitor
1610 Rottlerin
Reported PKCδ inhibitor
4221 TCS 21311
PKCα and PKCθ inhibitor. Also inhibits JAK3
2549 ZIP
Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Protein Kinase C Activators
Cat. No. Product Name / Activity
2383 Bryostatin 1
Protein kinase C activator
4054 PEP 005
Protein kinase C activator
4153 Phorbol 12,13-dibutyrate
Protein kinase C activator
1201 Phorbol 12-myristate 13-acetate
Protein kinase C activator
5343 TPPB
High affinity PKC activator; also APP modulator

Other
Cat. No. Product Name / Activity
3427 Oncrasin 1
Induces abnormal nuclear aggregation of PKCι; proapoptotic

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC α-, βI-, βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs ε-, δ-, θ- and η- isotypes) are also activated by DAG and phosphatidylserine.

The atypical PKCs (aPKCs ι- and ζ-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region.

The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

External sources of pharmacological information for Protein Kinase C :

Literature for Protein Kinase C

Tocris offers the following scientific literature for Protein Kinase C to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Protein Kinase C Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
cPKCα Human PRKCA NM_002737 P17252
Mouse Prkca NM_011101 P20444
Rat Prkca NM_001105713 P05696
cPKCβI Human PRKCB NM_212535 P05771
Mouse Prkcb NM_008855 P68404
Rat Prkcb NM_012713 P68403
cPKCγ Human PRKCG NM_002739 P05129
Mouse Prkcc NM_011102 P63318
Rat Prkcc NM_012628 P63319
nPKCδ Human PRKCD NM_006254 Q05655
Mouse Prkcd NM_011103 P28867
Rat Prkcd NM_133307 P09215
nPKCε Human PRKCE NM_005400 Q02156
Mouse Prkce NM_011104 P16054
Rat Prkce NM_017171 P09216
nPKCθ Human PRKCQ NM_006257 Q04759
Mouse Prkcq NM_008859 Q02111
nPKCη Human PRKCH NM_006255 P24723
Mouse Prkch NM_008856 P23298
Rat Prkch NM_031085 Q64617
aPKCι Human PRKCI NM_002740 P41743
Mouse Prkci NM_008857 Q62074
Rat Prkci EU517502 P97701
aPKCζ Human PRKCZ NM_002744 Q05513
Mouse Prkcz NM_008860 Q02956
Rat Prkcz NM_022507 P09217