GDC 0879

Pricing Availability   Qty
Description: Potent B-Raf inhibitor
Chemical Name: 2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for GDC 0879

GDC 0879 is a potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.

External Portal Information for GDC 0879

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GDC 0879 is reviewed on the chemical probes website.

Compound Libraries for GDC 0879

GDC 0879 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for GDC 0879

M. Wt 334.37
Formula C19H18N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 905281-76-7
PubChem ID 11717001
InChI Key DEZZLWQELQORIU-RELWKKBWSA-N
Smiles OCCN1N=C(C3=CC=NC=C3)C(C2=CC=C(/C(CC4)=N/O)C4=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GDC 0879

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.44 100

Preparing Stock Solutions for GDC 0879

The following data is based on the product molecular weight 334.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.95 mL 29.91 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.5 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Keywords: GDC 0879, GDC 0879 supplier, GDC0879, b-raf, braf, inhibitors, inhibits, potent, selective, Raf, Kinase, 4453, Tocris Bioscience

1 Citation for GDC 0879

Citations are publications that use Tocris products. Selected citations for GDC 0879 include:

Konstantinos et al (2021) Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis. Nat Commun 12 2424 PMID: 33893293


Do you know of a great paper that uses GDC 0879 from Tocris? Please let us know.

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