Small Monomeric GTPases

Small monomeric GTPases (also known as small G-proteins) are homologous to Gα proteins. This family of GTPases includes the RAS superfamily, which is further split into subfamilies based on structural, sequence and functional similarities. Each subfamily of small GTPases plays a slightly different role in the regulation of intracellular signaling pathways and cellular processes.

Targets
Literature

Small Monomeric GTPase Target Files

Like Gα proteins, small GTPases alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP) and so function as binary switches that regulate cytosolic signaling pathways. GDP/GTP cycling is controlled by two types of regulatory proteins that associate with small GTPases. Guanine exchange factors (GEFs) promote the formation of the active, GTP bound form of RAS proteins while GTPase activating proteins (GAPs) accelerate GTPase activity, promoting the inactive, GDP bound form.

Literature for Small Monomeric GTPases

Tocris offers the following scientific literature for Small Monomeric GTPases to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis