Hsp90

Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
1515 17-AAG
Selective Hsp90 inhibitor
4608 BIIB 021
Selective Hsp90 inhibitor
2435 CCT 018159
Hsp90 inhibitor
2610 17-DMAG hydrochloride
Water-soluble Hsp90 inhibitor
4701 EC 144
High affinity, potent and selective Hsp90 inhibitor
3387 Gedunin
Hsp90 inhibitor; exhibits anticancer and antimalarial activity
1368 Geldanamycin
Selective Hsp90 inhibitor
1629 Herbimycin A
Hsp90 inhibitor. Also Src family kinase inhibitor
3061 Macbecin I
Hsp90 inhibitor
3104 PU H71
Potent Hsp90 inhibitor
1589 Radicicol
Hsp90 inhibitor. Antifungal antibiotic

Other

Cat No Product Name / Activity
5480 KRIBB11
HSF1 inhibitor

Related Targets

Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of "client" proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37).

Hsp90 has been shown to interact with >100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90β isoform is constitutively expressed whereas the Hsp90α isoform is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilizing mutated oncogenic proteins.

Literature for Hsp90

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Hsp90 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Hsp90α
Class A Member 1
Human HSP90AA1 NM_005348 P07900
Mouse Hsp90aa1 NM_010480 P07901
Rat Hsp90aa1 NM_031098 Q63644
Hsp90α
Class A Member 2
Human HSP90AA2 NM_001040141 Q14568
Hsp90α
Class B Member 1
Human HSP90AB1 NM_007355 P08238
Mouse Hsp90ab1 NM_008302 P11499
Hsp90β Member 1 Human HSP90B1 NM_003299 P14625
Mouse Hsp90b1 NM_011631 P08113