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MEK, also known as Mitogen-activated protein kinase kinase and MAP2K, is a kinase enzyme that phosphorylates mitogen activated protein kinases (MAPKs), ERK, p38 and JNK. Seven MEK subtypes have been identified, all mediate cellular responses to different growth signals.
|Cat. No.||Product Name / Activity|
|Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation|
|Selective MEK5 and ERK5 inhibitor|
|Potent inhibitor of MEK1/2|
|Selective MEK inhibitor|
|Selective inhibitor of MEK1/2|
|Selective inhibitor of MEK1 and MEK2; brain penetrant|
|Potent and selective MEK inhibitor; orally bioavailable|
|Inactive analog of U0126 (Cat. No. 1144)|
|Potent, selective inhibitor of MEK1 and 2|
MEK, also known as Mitogen-activated protein kinase kinase and MAP2K, is a kinase enzyme that phosphorylates mitogen activated protein kinases (MAPKs), ERK, p38 and JNK. Seven MEK subtypes have so far been identified; MEK1 and MEK2 activate ERK, MEK3 and MEK4 activate p38 and MEK5 and MEK6 activate JNK. Upon activation, MAPKs can phosphorylate a variety of intracellular targets including transcription factors, transcriptional adaptor proteins, membrane and cytoplasmic substrates, and other protein kinases.
MEK is a key enzyme in the Ras/Raf/MEK/ERK signal transduction pathway and mediates cellular responses to different growth signals. This pathway is frequently deregulated in cancer, which makes these enzymes a candiate target for pharmacological antineoplastic treatment.
Tocris offers the following scientific literature for MEK to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|