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CST 905 New
Biological Activity for CST 905
CST 905 is a potent and selective BRAFV600E Degrader (PROTAC®) (DC50 = 18 nM). CST 905 comprises a ligand for the von Hippel Lindau (VHL) E3 ligase joined by a linker to a PLX-derived ligand. Unlike other BRAFV600E Degraders, CST 905 does not activate ERK.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data for CST 905
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CST 905
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CST 905
The following data is based on the product molecular weight 1025.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.98 mL||4.88 mL||9.75 mL|
|5 mM||0.2 mL||0.98 mL||1.95 mL|
|10 mM||0.1 mL||0.49 mL||0.98 mL|
|50 mM||0.02 mL||0.1 mL||0.2 mL|
References for CST 905
References are publications that support the biological activity of the product.
Miller et al (2022) Encoding BRAF inhibitor functions in protein degraders. RSC Med.Chem. 13 731 PMID: 35814929
If you know of a relevant reference for CST 905, please let us know.
View Related Products by Target
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Citations for CST 905
Citations are publications that use Tocris products.
Currently there are no citations for CST 905. Do you know of a great paper that uses CST 905 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia