Pricing Availability   Qty
Description: Kir6 (KATP) channel opener; active enantiomer of Cromakalim
Alternative Names: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Citations (3)
Reviews (1)

Biological Activity for Levcromakalim

Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.

Licensing Information

Sold under license

Technical Data for Levcromakalim

M. Wt 286.33
Formula C16H18N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94535-50-9
PubChem ID 93504
Smiles O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Levcromakalim

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.86 10

Preparing Stock Solutions for Levcromakalim

The following data is based on the product molecular weight 286.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.92 mL 174.62 mL 349.25 mL
0.5 mM 6.98 mL 34.92 mL 69.85 mL
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.7 mL 3.49 mL 6.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Levcromakalim

References for Levcromakalim

References are publications that support the biological activity of the product.

Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919 PMID: 2002472

Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945 PMID: 1467843

Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429 PMID: 1578358

If you know of a relevant reference for Levcromakalim, please let us know.

View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Activators

Keywords: Levcromakalim, Levcromakalim supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227, BRL, 38227, rectifier, 1378, Tocris Bioscience

3 Citations for Levcromakalim

Citations are publications that use Tocris products. Selected citations for Levcromakalim include:

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Lab Chip 10 e0121634 PMID: 25803863

Fike et al (2013) Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension. Pulm Circ 3 551 PMID: 24618540

Garland et al (2015) TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol 172 1114 PMID: 25323322

Do you know of a great paper that uses Levcromakalim from Tocris? Please let us know.

Reviews for Levcromakalim

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Levcromakalim?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Levcromakalim was used on BK channel opening properties compared to cromakalim.
By Anonymous on 11/28/2018
Assay Type: In Vitro
Species: Human

Levcromakalim was used on our lab to understand its BK channel opening properties compared to cromakalim. Results were reproducible.

review image