Levcromakalim

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Cat.No. 1378 - Levcromakalim | C16H18N2O3 | CAS No. 94535-50-9
Description: Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377)
Alternative Names: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.

Licensing Information

Sold under license

Technical Data

M. Wt 286.33
Formula C16H18N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94535-50-9
PubChem ID 93504
InChI Key TVZCRIROJQEVOT-CABCVRRESA-N
Smiles O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.86 10

Preparing Stock Solutions

The following data is based on the product molecular weight 286.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919 PMID: 2002472

Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945 PMID: 1467843

Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429 PMID: 1578358


If you know of a relevant reference for Levcromakalim, please let us know.

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Keywords: KATP channel openers Potassium KIR Channels Inward Rectifier K+ BRL38227 BRL 38227 Inward rectifier Potassium Channels

1 Citation for Levcromakalim

Citations are publications that use Tocris products. Selected citations for Levcromakalim include:

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Lab Chip 10 e0121634 PMID: 25803863


Do you know of a great paper that uses Levcromakalim from Tocris? If so please let us know.

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Pathways for Levcromakalim

Protocols

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