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Biological Activity for VU 0071063
VU 0071063 is a selective activator of SUR1 Kir6.2 channels and pancreatic β-cell KATP channels (EC50 = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca2+ influx. VU 0071063 is active in vivo and brain penetrant.
Technical Data for VU 0071063
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 0071063
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for VU 0071063
The following data is based on the product molecular weight 326.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||61.27 mL||306.37 mL||612.75 mL|
|0.25 mM||12.25 mL||61.27 mL||122.55 mL|
|0.5 mM||6.13 mL||30.64 mL||61.27 mL|
|2.5 mM||1.23 mL||6.13 mL||12.25 mL|
References for VU 0071063
References are publications that support the biological activity of the product.
Raphemot et al (2014) Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol.Pharmacol. 85 858 PMID: 24646456
Kharade et al (2019) Structure-activity relationships, pharmacokinetics, and pharmacodynamics of the Kir6.2/SUR1-specific channel opener VU0071063. J.Pharmacol.Exp.Ther. 370 350 PMID: 31201216
If you know of a relevant reference for VU 0071063, please let us know.
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Keywords: VU 0071063, VU 0071063 supplier, VU0071063, selective, activators, potassium, channels, SUR1, Kir6.2, pancreatic, beta, cell, b-cells, Inward, rectifier, Potassium, Channels, 7057, Tocris Bioscience
Citations for VU 0071063
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Literature in this Area
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