ML 133 hydrochloride

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Cat.No. 4549 - ML 133 hydrochloride | C19H19NO.HCl | CAS No. 1222781-70-5
Description: Kir2 channel blocker
Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (3)

Biological Activity

Selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).

Technical Data

M. Wt 313.82
Formula C19H19NO.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1222781-70-5
PubChem ID 44247466
InChI Key NGQIBUUFXDPHKT-UHFFFAOYSA-N
Smiles COC(C=C3)=CC=C3CNCC1=C(C=CC=C2)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 313.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.87 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2011) Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 6 845 PMID: 21615117

Wu et al (2010) A potent and selective small molecule Kir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro PMID: 21433384


If you know of a relevant reference for ML 133 hydrochloride, please let us know.

View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: ML 133 hydrochloride, ML 133 hydrochloride supplier, ML133, hydrochloride, Kir2, Kir2.x, Kir2.1, Kir2.6, Kir2.2, Kir2.3, inhibitors, inhibits, inward, rectifier, potassium, channels, IRK1, KCNJ2, IRK2, hIRK, IRK3, hIRK2, Inward, Potassium, Channels, 4549, Tocris Bioscience

3 Citations for ML 133 hydrochloride

Citations are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:

Siddiqui et al (2016) Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation 13 66 PMID: 27009332

Lam and Schlichter (2015) Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Nat Commun 9 185 PMID: 26029054

Lively et al (2018) Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. Front Cell Neurosci 12 115 PMID: 29780305


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Reviews for ML 133 hydrochloride

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ML 133 hydrochloride was used on Calcium-activated 6T & 1P potassium channels.
By Anonymous on 02/27/2019
Species: Human

ML 133 hydrochloride was used on Calcium-activated 6T & 1P potassium channels. The product works ideally on cell culture labs and would highly recommend.

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