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Cat.No. 6086 - AMP PNP | C10H13Li4N6O12P3 | CAS No. 72957-42-7
Description: Kir6 blocker; non-hydrolyzable AMP analog
Chemical Name: Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
Purity: ≥90% (HPLC)

Biological Activity

Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

Technical Data

M. Wt 529.93
Formula C10H13Li4N6O12P3
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 72957-42-7
PubChem ID 44134521
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 26.5 50

Preparing Stock Solutions

The following data is based on the product molecular weight 529.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.44 mL 18.87 mL
5 mM 0.38 mL 1.89 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID: 2412134

Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID: 4326768

Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID: 7805625

If you know of a relevant reference for AMP PNP, please let us know.

View Related Products by Product Action

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Pathways for AMP PNP


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