AMP PNP

Pricing Availability Delivery Time Qty
Cat.No. 6086 - AMP PNP | C10H13Li4N6O12P3 | CAS No. 72957-42-7
Description: Kir6 blocker; non-hydrolyzable AMP analog
Chemical Name: Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
Purity: ≥90% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

Technical Data

M. Wt 529.93
Formula C10H13Li4N6O12P3
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 72957-42-7
PubChem ID 44134521
InChI Key FDBDJIGGLGUOPP-UHFFFAOYSA-J
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.5 50

Preparing Stock Solutions

The following data is based on the product molecular weight 529.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.44 mL 18.87 mL
5 mM 0.38 mL 1.89 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID: 2412134

Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID: 4326768

Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID: 7805625


If you know of a relevant reference for AMP PNP, please let us know.

View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: AMP PNP, supplier, AMPPNP, non-hydrolyzable, non-hydrolysable, AMP, analog, adenylyl-imidodiphosphate, tetralithium, salt, Kir6, channel, blockers, blocks, KATP, inward, rectifier, potassium, current, Inward, rectifier, Potassium, Channels, Tocris Bioscience

Citations for AMP PNP

Citations are publications that use Tocris products.

Currently there are no citations for AMP PNP. Do you know of a great paper that uses AMP PNP from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pathways for AMP PNP

Protocols

TODO: Add Protocols