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Description: Kir6 blocker; non-hydrolyzable AMP analog
Chemical Name: Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
Purity: ≥90% (HPLC)
Citations (2)
Reviews (1)

Biological Activity for AMP PNP

AMP PNP is a non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

Technical Data for AMP PNP

M. Wt 529.93
Formula C10H13Li4N6O12P3
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 72957-42-7
PubChem ID 44134521
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMP PNP

Solvent Max Conc. mg/mL Max Conc. mM
water 26.5 50

Preparing Stock Solutions for AMP PNP

The following data is based on the product molecular weight 529.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.77 mL 18.87 mL 37.74 mL
2.5 mM 0.75 mL 3.77 mL 7.55 mL
5 mM 0.38 mL 1.89 mL 3.77 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets for AMP PNP

Certificate of Analysis / Product Datasheet
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References for AMP PNP

References are publications that support the biological activity of the product.

Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID: 2412134

Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID: 4326768

Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID: 7805625

If you know of a relevant reference for AMP PNP, please let us know.

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Keywords: AMP PNP, AMP PNP supplier, AMPPNP, non-hydrolyzable, non-hydrolysable, AMP, analog, adenylyl-imidodiphosphate, tetralithium, salt, Kir6, channel, blockers, blocks, KATP, inward, rectifier, potassium, current, Inward, Potassium, Channels, 6086, Tocris Bioscience

2 Citations for AMP PNP

Citations are publications that use Tocris products. Selected citations for AMP PNP include:

Shimizu et al (2021) Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin. Biochim.Biophys.Acta Biomembr. 1864 183782 PMID: 34555418

Roland et al (2021) Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv 7 eabk2392 PMID: 34936443

Do you know of a great paper that uses AMP PNP from Tocris? Please let us know.

Reviews for AMP PNP

Average Rating: 5 (Based on 1 Review.)

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AMP PNP was used to estimate Kir blocking on Natural Killer cells..
By Anonymous on 01/16/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: NK cells

AMP PNP was used to estimate Kir blocking on Natural Killer cells at increasing concentrations.

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