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Biological Activity for AMP PNP
AMP PNP is a non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.
Technical Data for AMP PNP
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AMP PNP
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AMP PNP
The following data is based on the product molecular weight 529.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.77 mL||18.87 mL||37.74 mL|
|2.5 mM||0.75 mL||3.77 mL||7.55 mL|
|5 mM||0.38 mL||1.89 mL||3.77 mL|
|25 mM||0.08 mL||0.38 mL||0.75 mL|
References for AMP PNP
References are publications that support the biological activity of the product.
Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID: 2412134
Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID: 4326768
Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID: 7805625
If you know of a relevant reference for AMP PNP, please let us know.
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Keywords: AMP PNP, AMP PNP supplier, AMPPNP, non-hydrolyzable, non-hydrolysable, AMP, analog, adenylyl-imidodiphosphate, tetralithium, salt, Kir6, channel, blockers, blocks, KATP, inward, rectifier, potassium, current, Inward, Potassium, Channels, 6086, Tocris Bioscience
2 Citations for AMP PNP
Citations are publications that use Tocris products. Selected citations for AMP PNP include:
Roland et al (2021) Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv 7 eabk2392 PMID: 34936443
Shimizu et al (2021) Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin. Biochim.Biophys.Acta Biomembr. 1864 183782 PMID: 34555418
Do you know of a great paper that uses AMP PNP from Tocris? Please let us know.
Reviews for AMP PNP
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
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