Repaglinide

Pricing Availability   Qty
Cat.No. 3805 - Repaglinide | C27H36N2O4 | CAS No. 135062-02-1
Description: Kir6 (KATP) channel blocker
Alternative Names: AG-EE 623ZW
Chemical Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Kir6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (Kd = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.

Compound Libraries

Repaglinide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 452.59
Formula C27H36N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 135062-02-1
PubChem ID 65981
InChI Key FAEKWTJYAYMJKF-QHCPKHFHSA-N
Smiles O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.26 100
ethanol 45.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 452.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs. Br.J.Pharmacol. 121 1597 PMID: 9283692

Hansen et al (2005) Kir6.2-dependent high-affinity repaglinide binding to β-cell KATP channels. Br.J.Pharmacol. 144 551 PMID: 15678092


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View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: Repaglinide, Repaglinide supplier, K+, channel, pore, blockers, KATP, Blocks, SUR1, KIR6, Kir6.2, sulphonylurea, receptor, inward, rectifier, AG-EE, 623ZW, Inward, Potassium, Channels, 3805, Tocris Bioscience

Citations for Repaglinide

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