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Description: Kir6 (KATP) channel blocker
Alternative Names: AG-EE 623ZW
Chemical Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid
Purity: ≥99% (HPLC)

Biological Activity for Repaglinide

Repaglinide is a Kir6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (Kd = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.

Compound Libraries for Repaglinide

Repaglinide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Repaglinide

M. Wt 452.59
Formula C27H36N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 135062-02-1
PubChem ID 65981
Smiles O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Repaglinide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.26 100
ethanol 45.26 100

Preparing Stock Solutions for Repaglinide

The following data is based on the product molecular weight 452.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for Repaglinide

References are publications that support the biological activity of the product.

Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repagl. in rats and dogs. Br.J.Pharmacol. 121 1597 PMID: 9283692

Hansen et al (2005) Kir6.2-dependent high-affinity repagl. binding to β-cell KATP channels. Br.J.Pharmacol. 144 551 PMID: 15678092

If you know of a relevant reference for Repaglinide, please let us know.

View Related Products by Product Action

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Citations for Repaglinide

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Currently there are no citations for Repaglinide. Do you know of a great paper that uses Repaglinide from Tocris? Please let us know.

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