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Biological Activity for ML 297
ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.
Sold under license from Vanderbilt University
Compound Libraries for ML 297
Technical Data for ML 297
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 297
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML 297
The following data is based on the product molecular weight 328.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.05 mL||15.23 mL||30.46 mL|
|5 mM||0.61 mL||3.05 mL||6.09 mL|
|10 mM||0.3 mL||1.52 mL||3.05 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References for ML 297
References are publications that support the biological activity of the product.
Kaufmann et al (2013) ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 4 1278 PMID: 23730969
Wen et al (2013) Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg.Med.Chem.Lett. 23 4562 PMID: 23838260
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Keywords: ML 297, ML 297 supplier, ML297, selective, Kir3.1, GIRK1, channels, activators, inward, rectifying, rectifiers, potassium, K+, epilepsy, Inward, rectifier, Potassium, Channels, 5380, Tocris Bioscience
Citations for ML 297
Citations are publications that use Tocris products.
Currently there are no citations for ML 297. Do you know of a great paper that uses ML 297 from Tocris? Please let us know.
Reviews for ML 297
Average Rating: 5 (Based on 1 Review.)
Have you used ML 297?
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ML 297 and ML 277 was used on our University labs to understand potassium channel activation percentage at increasing concentrations. ML 297 worked ideally and the data obtained with the product was consistent throughout the experiment.
Literature in this Area
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