Selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.
Sold under license from Vanderbilt University
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 328.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.05 mL||15.23 mL||30.46 mL|
|5 mM||0.61 mL||3.05 mL||6.09 mL|
|10 mM||0.3 mL||1.52 mL||3.05 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References are publications that support the biological activity of the product.
Kaufmann et al (2013) ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 4 1278 PMID: 23730969
Wen et al (2013) Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg.Med.Chem.Lett. 23 4562 PMID: 23838260
If you know of a relevant reference for ML 297, please let us know.
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Keywords: ML 297, ML 297 supplier, ML297, selective, Kir3.1, GIRK1, channels, activators, inward, rectifying, rectifiers, potassium, K+, epilepsy, Inward, rectifier, Potassium, Channels, 5380, Tocris Bioscience
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