Pricing Availability   Qty
Description: Kir6 channel (KATP) opener
Chemical Name: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for Minoxidil

Minoxidil is an antihypertensive. Antialopecia agent. Kir6 channel (KATP) activator.

Compound Libraries for Minoxidil

Minoxidil is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Minoxidil

M. Wt 209.25
Formula C9H15N5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 38304-91-5
PubChem ID 4201
Smiles NC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Minoxidil

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 5.23 25
DMSO 5.23 25 with gentle warming

Preparing Stock Solutions for Minoxidil

The following data is based on the product molecular weight 209.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 19.12 mL 95.58 mL 191.16 mL
1.25 mM 3.82 mL 19.12 mL 38.23 mL
2.5 mM 1.91 mL 9.56 mL 19.12 mL
12.5 mM 0.38 mL 1.91 mL 3.82 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Minoxidil

Certificate of Analysis / Product Datasheet
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References for Minoxidil

References are publications that support the biological activity of the product.

Lachgar et al (1998) Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br.J.Dermatol. 138 407 PMID: 9580790

Meisheri et al (1993) Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem.Pharmacol. 45 271 PMID: 8435087

Tsoporis et al (1993) Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats. J.Hypertens. 11 1337 PMID: 8133016

Merck Index 12 6290

If you know of a relevant reference for Minoxidil, please let us know.

View Related Products by Product Action

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Keywords: Minoxidil, Minoxidil supplier, K+, channel, KATP, openers, Potassium, KIR, Channels, Inward, Rectifier, antihypertensive, activators, Kir6, rectifier, 0583, Tocris Bioscience

1 Citation for Minoxidil

Citations are publications that use Tocris products. Selected citations for Minoxidil include:

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792

Do you know of a great paper that uses Minoxidil from Tocris? Please let us know.

Reviews for Minoxidil

Average Rating: 5 (Based on 1 Review.)

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Minoxidil used to study BK channel opening.
By Sadequl Islam on 11/27/2018
Assay Type: In Vitro
Species: Human

Minoxidil was used based on its history as a potent potassium channel opener. It was used to study BK channel opening.

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