Minoxidil

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Cat.No. 0583 - Minoxidil | C9H15N5O | CAS No. 38304-91-5
Description: Kir6 channel (KATP) opener
Chemical Name: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antihypertensive. Antialopecia agent. Kir6 channel (KATP) activator.

Compound Libraries

Minoxidil is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 209.25
Formula C9H15N5O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 38304-91-5
PubChem ID 4201
InChI Key ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Smiles NC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.23 25mM with gentle warming
ethanol 5.23 25

Preparing Stock Solutions

The following data is based on the product molecular weight 209.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.78 mL 23.89 mL 47.79 mL
5 mM 0.96 mL 4.78 mL 9.56 mL
10 mM 0.48 mL 2.39 mL 4.78 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lachgar et al (1998) Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br.J.Dermatol. 138 407 PMID: 9580790

Meisheri et al (1993) Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem.Pharmacol. 45 271 PMID: 8435087

Tsoporis et al (1993) Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats. J.Hypertens. 11 1337 PMID: 8133016

Merck Index 12 6290 PMID:


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Citations for Minoxidil

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