Glutamate (Metabotropic) Group II Receptors

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Products
Background
Literature (5)
Gene Data

Glutamate (Metabotropic) Group II Receptor Agonists

Cat. No. Product Name / Activity
0284 (1S,3R)-ACPD
Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
0187 (±)-trans-ACPD
Group I and II mGlu agonist
1208 (2R,4R)-APDC
Highly selective group II agonist
0323 (S)-4-Carboxyphenylglycine
Weak group II mGlu agonist; also Group I mGlu antagonist
0333 L-CCG-l
Potent group II mGlu agonist
0975 DCG IV
Highly potent group II mGlu agonist; also NMDA agonist
3246 LY 354740
Potent and highly selective group II mGlu agonist
2453 LY 379268
Highly selective group II mGlu agonist
5064 LY 379268 disodium salt
Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)

Glutamate (Metabotropic) Group II Receptor Antagonists

Cat. No. Product Name / Activity
1209 LY 341495
Highly potent and selective group II mGlu antagonist
4062 LY 341495 disodium salt
Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)
2913 Ro 64-5229
Selective, non-competitive mGlu2 antagonist

Glutamate (Metabotropic) Group II Receptor Modulators

Cat. No. Product Name / Activity
4048 BINA
Selective positive allosteric modulator of mGlu2 receptors
3283 LY 487379 hydrochloride
Selective positive allosteric modulator of mGlu2 receptors
4982 ML 337
Selective negative allosteric modulator of mGlu3 receptors
4388 MNI 137
Selective negative allosteric modulator of group II mGlu receptors
5362 TASP 0433864
Selective positive allosteric modulator of mGlu2 receptors
6928 VU 6001966
Potent and selective negative allosteric modulator of mGlu2 receptors

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

External sources of pharmacological information for Glutamate (Metabotropic) Group II Receptors :

Literature for Glutamate (Metabotropic) Group II Receptors

Tocris offers the following scientific literature for Glutamate (Metabotropic) Group II Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Glutamate (Metabotropic) Group II Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
mGlu2 Human GRM2 NM_000839 Q14416
Mouse Grm2 AK034263 Q14BI2
Rat Grm2 NM_001105711 P31421
mGlu3 Human GRM3 NM_000840 Q14832
Mouse Grm3 NM_181850 Q9QYS2
Rat Grm3 NM_001105712 P31422