Glutamate (Metabotropic) Group II Receptors

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0284 (1S,3R)-ACPD
Group II/group I mGlu agonist
0186 cis-ACPD
Selective group II agonist. Also potent NMDA agonist
0187 (±)-trans-ACPD
Group II/group I mGlu agonist
1208 (2R,4R)-APDC
Highly selective group II agonist
0329 (S)-3-Carboxy-4-hydroxyphenylglycine
Selective group II mGlu agonist, also group I mGlu antagonist
0320 (S)-4-Carboxy-3-hydroxyphenylglycine
Group II agonist/group I antagonist
0323 (S)-4-Carboxyphenylglycine
Group I mGlu antagonist/weak group II agonist
0333 L-CCG-l
Potent group II mGlu agonist
0975 DCG IV
Very potent, selective group II mGlu agonist. Also NMDA agonist
3246 LY 354740
Potent and highly selective group II mGlu agonist
2453 LY 379268
Highly selective group II mGlu agonist
5064 LY 379268 disodium salt
Sodium salt of LY 379268 (Cat. No. 2453); selective group II mGlu receptor agonist
3272 (±)-LY 395756
Mixed mGlu2 agonist/ mGlu3 antagonist
0711 MAP4
Potent group II mGlu agonist. Also specific group III mGlu antagonist
3332 NPEC-caged-LY 379268
Caged group II mGlu receptor agonist
0391 Spaglumic acid
Selective mGlu3 agonist

Antagonists

Cat No Product Name / Activity
1073 (RS)-APICA
Selective group II antagonist
1009 E4CPG
Group II/group I mGlu antagonist
0971 EGLU
Highly selective group II mGlu antagonist
1209 LY 341495
Highly potent, selective group II antagonist
4062 LY 341495 disodium salt
Disodium salt of LY 341495 (Cat. No. 1209)
0336 (RS)-MCPG
Non-selective mGlu antagonist
3696 (RS)-MCPG disodium salt
Non-selective mGlu antagonist
0337 (S)-MCPG
Non-selective mGlu antagonist. Active isomer of Cat. No. 0336
0854 MSPG
Group II/group III mGlu antagonist
0855 MTPG
Group II/group III mGlu antagonist. More selective for group II than group III
2913 Ro 64-5229
Selective, non-competitive mGlu2 antagonist

Modulators

Cat No Product Name / Activity
4048 BINA
Selective positive allosteric modulator of mGlu2
3949 CBiPES hydrochloride
Positive allosteric modulator of mGlu2
4969 LY 2389575 hydrochloride
Selective negative allosteric modulator of mGlu3
3283 LY 487379 hydrochloride
Positive allosteric modulator selective for mGlu2
4976 ML 289
Selective negative allosteric modulator of mGlu3
4982 ML 337
Selective negative allosteric modulator of mGlu3
4388 MNI 137
Selective negative allosteric modulator of group II mGlu receptors
5362 TASP 0433864
Selective mGlu2 receptor positive allosteric modulator

Activators

Cat No Product Name / Activity
4120 Xanthurenic acid
Selectively activates group II mGlu receptors

Ligand-sets

Cat No Product Name / Activity
1827 Group II mGlu Receptor Tocriset™
Selection of 5 group II mGlu receptor ligands (Cat. Nos. 1208, 0975, 1209, 0971 and 0337)
1829 Mixed mGlu Receptor Tocriset™
Selection of 5 mixed mGlu receptor ligands (Cat. Nos. 0805, 0975, 0103, 0337 and 1209)

Other

Cat No Product Name / Activity
4936 Clozapine N-oxide
Activator of muscarinic DREAADs

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

External sources of pharmacological information for Glutamate (Metabotropic) Group II Receptors :

Literature for Glutamate (Metabotropic) Group II Receptors

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GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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Metabotropic Glutamate Receptors

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Glutamate (Metabotropic) Group II Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
mGlu2 Human GRM2 NM_000839 Q14416
Mouse Grm2 AK034263 Q14BI2
Rat Grm2 NM_001105711 P31421
mGlu3 Human GRM3 NM_000840 Q14832
Mouse Grm3 NM_181850 Q9QYS2
Rat Grm3 NM_001105712 P31422