Ro 64-5229

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Cat.No. 2913 - Ro 64-5229 | C17H19Cl2N3O | CAS No. 246852-46-0
Description: Selective, non-competitive mGlu2 antagonist
Chemical Name: (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).

Technical Data

M. Wt 352.26
Formula C17H19Cl2N3O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 246852-46-0
PubChem ID 10428048
InChI Key STCVFKBRXOEQRF-YBEGLDIGSA-N
Smiles ClC1=CC=CC(Cl)=C1/C(OC3CCCCCC3)=C/N2N=CN=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.23 100
ethanol 35.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 352.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.39 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Kolczewski et al (1999) Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 9 2173 PMID: 10465539

Brauner-Osbourne et al (2007) Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 8 169 PMID: 17266540


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