Metabotropic Glutamate Receptors Scientific Review

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Metabotropic Glutamate Receptors Scientific Review

Francine C Acher, Université René Descartes-Paris V

Review excerpt: "Glutamate has been shown to be involved in many neuropathologies, such as anxiety, pain, ischemia, Parkinson's disease, epilepsy and schizophrenia. Thus, because of their modulating properties, mGlu receptors are recognized as promising therapeutic targets. It is expected that drugs acting at mGlu receptors will regulate the glutamatergic system without affecting normal synaptic transmission."