MNI 137

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Description: Selective negative allosteric modulator of group II mGlu receptors
Chemical Name: 4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for MNI 137

MNI 137 is a selective negative allosteric modulator of group II mGlu receptors (IC50 values are 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu1, mGlu4, mGlu5 or mGlu8 receptors in a calcium mobilization assay.

Compound Libraries for MNI 137

MNI 137 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MNI 137

M. Wt 341.16
Formula C15H9BrN4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 946619-21-2
PubChem ID 25210562
Smiles O=C1CC(C3=CC=NC(C#N)=C3)=NC2=C(C=C(Br)C=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MNI 137

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.06 50

Preparing Stock Solutions for MNI 137

The following data is based on the product molecular weight 341.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.86 mL 29.31 mL 58.62 mL
2.5 mM 1.17 mL 5.86 mL 11.72 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
25 mM 0.12 mL 0.59 mL 1.17 mL

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References for MNI 137

References are publications that support the biological activity of the product.

Hemstapat et al (2007) A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 322 254 PMID: 17416742

If you know of a relevant reference for MNI 137, please let us know.

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Citations for MNI 137

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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