Glutamate (Metabotropic) Group III Receptors

Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.

Products
Background
Literature (8)
Gene Data

Glutamate (Metabotropic) Group III Receptor Agonists

Cat. No. Product Name / Activity
1111 ACPT-I
Group III mGlu agonist
2385 AMN 082 dihydrochloride
Selective mGlu7 agonist
0103 L-AP4
Selective group III mGlu agonist
1302 (S)-3,4-DCPG
Potent and selective mGlu8a agonist

Glutamate (Metabotropic) Group III Receptor Antagonists

Cat. No. Product Name / Activity
0972 CPPG
Potent group III mGlu antagonist
1209 LY 341495
Group II/III antagonist
0803 MSOP
Specific group III mGlu antagonist
5248 XAP 044
Potent and selective mGlu7 antagonist

Glutamate (Metabotropic) Group III Receptor Modulators

Cat. No. Product Name / Activity
5715 (±)-ADX 71743
Negative allosteric modulator of mGlu7 receptors; brain penetrant
1212 MPEP hydrochloride
Positive allosteric modulator of mGlu4 receptors; also potent mGlu5 antagonist
5378 VU 0422288
Selective positive allosteric modulator of group III mGlu receptors
6893 VU 6005649
Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant

Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. mGlu group III receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in spatial learning and memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8 receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1) respectively.

External sources of pharmacological information for Glutamate (Metabotropic) Group III Receptors :

Literature for Glutamate (Metabotropic) Group III Receptors

Tocris offers the following scientific literature for Glutamate (Metabotropic) Group III Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Glutamate (Metabotropic) Group III Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
mGlu4 Human GRM4 NM_000841 Q14833
Mouse Grm4 NM_001013385 Q68EF4
Rat Grm4 NM_022666 P31423
mGlu6 Human GRM6 NM_000843 O15303
Mouse Grm6 BC034118 Q5NCH9
Rat Grm6 NM_022920 P35349
mGlu7 Human GRM7 NM_000844 Q14831
Mouse Grm7 NM_177328 Q68ED2
Rat Grm7 NM_031040 P35400
mGlu8 Human GRM8 NM_000845 O00222
Mouse Grm8 NM_008174 P47743
Rat Grm8 NM_022202 P70579