Glutamate (Metabotropic) Group III Receptors
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.
Glutamate (Metabotropic) Group III Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1111 | ACPT-I |
| Group III mGlu agonist | |
| 2385 | AMN 082 dihydrochloride |
| Selective mGlu7 agonist | |
| 0103 | L-AP4 |
| Selective group III mGlu agonist | |
| 1302 | (S)-3,4-DCPG |
| Potent and selective mGlu8a agonist | |
Glutamate (Metabotropic) Group III Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 0972 | CPPG |
| Potent group III mGlu antagonist | |
| 1209 | LY 341495 |
| Group II/III antagonist | |
| 0803 | MSOP |
| Specific group III mGlu antagonist | |
| 5248 | XAP 044 |
| Potent and selective mGlu7 antagonist | |
Glutamate (Metabotropic) Group III Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 5715 | (±)-ADX 71743 |
| Negative allosteric modulator of mGlu7 receptors; brain penetrant | |
| 1212 | MPEP hydrochloride |
| Positive allosteric modulator of mGlu4 receptors; also potent mGlu5 antagonist | |
| 5378 | VU 0422288 |
| Selective positive allosteric modulator of group III mGlu receptors | |
| 6893 | VU 6005649 |
| Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | |
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. mGlu group III receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in spatial learning and memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8 receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1) respectively.
External sources of pharmacological information for Glutamate (Metabotropic) Group III Receptors :
Literature for Glutamate (Metabotropic) Group III Receptors
Tocris offers the following scientific literature for Glutamate (Metabotropic) Group III Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy Poster
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia Poster
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
Glutamate (Metabotropic) Group III Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| mGlu4 | Human | GRM4 | NM_000841 | Q14833 |
| Mouse | Grm4 | NM_001013385 | Q68EF4 | |
| Rat | Grm4 | NM_022666 | P31423 | |
| mGlu6 | Human | GRM6 | NM_000843 | O15303 |
| Mouse | Grm6 | BC034118 | Q5NCH9 | |
| Rat | Grm6 | NM_022920 | P35349 | |
| mGlu7 | Human | GRM7 | NM_000844 | Q14831 |
| Mouse | Grm7 | NM_177328 | Q68ED2 | |
| Rat | Grm7 | NM_031040 | P35400 | |
| mGlu8 | Human | GRM8 | NM_000845 | O00222 |
| Mouse | Grm8 | NM_008174 | P47743 | |
| Rat | Grm8 | NM_022202 | P70579 |
Our Pain guide highlights over 280 products for Pain research.
Request copyRequest PDF
Our Metabotropic Glutamate Receptor review gives an overview of the pharmacological ligands used to study the mGlu receptors.
Request copyRequest PDF
Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
Request copyDownload PDF
Written by Alsa Pitkänen and Xavier Ekolle Ndode-Ekane, this poster summarizes current knowledge about how epilepsy develops.
Request copyDownload PDFWritten by Clea Warburton and Zafar Bashir
Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression.
Request copyDownload PDFWritten by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
Request copyDownload PDFWritten by Justin M. Saunders and Javier González-Maeso
Our Schizophrenia poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.
Request copyDownload PDF