Glutamate (Metabotropic) Group III Receptors
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.
Glutamate (Metabotropic) Group III Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1111 | ACPT-I |
| Group III mGlu agonist | |
| 2385 | AMN 082 dihydrochloride |
| Selective mGlu7 agonist | |
| 0103 | L-AP4 |
| Selective group III mGlu agonist | |
| 1302 | (S)-3,4-DCPG |
| Potent and selective mGlu8a agonist | |
Glutamate (Metabotropic) Group III Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 0972 | CPPG |
| Potent group III mGlu antagonist | |
| 1209 | LY 341495 |
| Group II/III antagonist | |
| 0803 | MSOP |
| Specific group III mGlu antagonist | |
| 5248 | XAP 044 |
| Potent and selective mGlu7 antagonist | |
Glutamate (Metabotropic) Group III Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 5715 | (±)-ADX 71743 |
| Negative allosteric modulator of mGlu7 receptors; brain penetrant | |
| 1212 | MPEP hydrochloride |
| Positive allosteric modulator of mGlu4 receptors; also potent mGlu5 antagonist | |
| 5378 | VU 0422288 |
| Selective positive allosteric modulator of group III mGlu receptors | |
| 6893 | VU 6005649 |
| Positive allosteric modulator of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | |
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. mGlu group III receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in spatial learning and memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8 receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1) respectively.
External sources of pharmacological information for Glutamate (Metabotropic) Group III Receptors :
Literature for Glutamate (Metabotropic) Group III Receptors
Tocris offers the following scientific literature for Glutamate (Metabotropic) Group III Receptors to showcase our products. We invite you to request* your copy today!
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Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Glutamate (Metabotropic) Group III Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| mGlu4 | Human | GRM4 | NM_000841 | Q14833 |
| Mouse | Grm4 | NM_001013385 | Q68EF4 | |
| Rat | Grm4 | NM_022666 | P31423 | |
| mGlu6 | Human | GRM6 | NM_000843 | O15303 |
| Mouse | Grm6 | BC034118 | Q5NCH9 | |
| Rat | Grm6 | NM_022920 | P35349 | |
| mGlu7 | Human | GRM7 | NM_000844 | Q14831 |
| Mouse | Grm7 | NM_177328 | Q68ED2 | |
| Rat | Grm7 | NM_031040 | P35400 | |
| mGlu8 | Human | GRM8 | NM_000845 | O00222 |
| Mouse | Grm8 | NM_008174 | P47743 | |
| Rat | Grm8 | NM_022202 | P70579 |
Our Metabotropic Glutamate Receptor review gives an overview of the pharmacological ligands used to study the mGlu receptors.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
Request copyDownload PDFWritten by Clea Warburton and Zafar Bashir
Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression.
Request copyDownload PDFWritten by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
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