LY 341495 disodium salt

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Description: Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)
Chemical Name: (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt
Purity: ≥97% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (4)

Biological Activity for LY 341495 disodium salt

LY 341495 disodium salt is a Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).

Technical Data for LY 341495 disodium salt

M. Wt 397.33
Formula C20H17NNa2O5
Storage Store at -20°C
Purity ≥97% (HPLC)
PubChem ID 90488907
InChI Key UYFREPWOVKMBOV-AUZVYACCSA-L
Smiles [Na+].[Na+].[H][C@@]1(C[C@@H]1C([O-])=O)[C@@](N)(CC1C2=CC=CC=C2OC2=C1C=CC=C2)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 341495 disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.73 100

Preparing Stock Solutions for LY 341495 disodium salt

The following data is based on the product molecular weight 397.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for LY 341495 disodium salt

Certificate of Analysis / Product Datasheet
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View all Glutamate (Metabotropic) Group II Receptor Antagonists

Keywords: LY 341495 disodium salt, LY 341495 disodium salt supplier, LY341495, disodium, salt, group, II, mglu, metabotropic, glutamate, receptors, antagonists, Glutamate, (Metabotropic), Group, Receptors, 4062, Tocris Bioscience

8 Citations for LY 341495 disodium salt

Citations are publications that use Tocris products. Selected citations for LY 341495 disodium salt include:

Michel K et al (2020) Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell Rep 32 108182 PMID: 32966786

Javier et al (2020) Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells. Cell Chem Biol 27 1308-1317.e4 PMID: 32726588

Jean-Philippe et al (2021) Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations. Cell Rep 36 109648 PMID: 34469715

David D et al (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102 420-434.e8 PMID: 30826183


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

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