LY 341495 disodium salt

Pricing Availability   Qty
Description: Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)
Chemical Name: (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt
Purity: ≥97% (HPLC)
Citations (8)
Literature (4)

Biological Activity for LY 341495 disodium salt

LY 341495 disodium salt is a Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).

Technical Data for LY 341495 disodium salt

M. Wt 397.33
Formula C20H17NNa2O5
Storage Store at -20°C
Purity ≥97% (HPLC)
PubChem ID 90488907
Smiles [Na+].[Na+].[H][C@@]1(C[C@@H]1C([O-])=O)[C@@](N)(CC1C2=CC=CC=C2OC2=C1C=CC=C2)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 341495 disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 39.73 100

Preparing Stock Solutions for LY 341495 disodium salt

The following data is based on the product molecular weight 397.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for LY 341495 disodium salt

Certificate of Analysis / Product Datasheet
Select another batch:

View Related Products by Product Action

View all Glutamate (Metabotropic) Group II Receptor Antagonists

Keywords: LY 341495 disodium salt, LY 341495 disodium salt supplier, LY341495, disodium, salt, group, II, mglu, metabotropic, glutamate, receptors, antagonists, Glutamate, (Metabotropic), Group, Receptors, 4062, Tocris Bioscience

8 Citations for LY 341495 disodium salt

Citations are publications that use Tocris products. Selected citations for LY 341495 disodium salt include:

Michel K et al (2020) Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell Rep 32 108182 PMID: 32966786

Javier et al (2020) Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells. Cell Chem Biol 27 1308-1317.e4 PMID: 32726588

Jean-Philippe et al (2021) Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations. Cell Rep 36 109648 PMID: 34469715

David D et al (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102 420-434.e8 PMID: 30826183

Do you know of a great paper that uses LY 341495 disodium salt from Tocris? Please let us know.

Reviews for LY 341495 disodium salt

There are currently no reviews for this product. Be the first to review LY 341495 disodium salt and earn rewards!

Have you used LY 341495 disodium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.