BINA

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Description: Selective positive allosteric modulator of mGlu2 receptors
Alternative Names: Biphenyl-indanone A
Chemical Name: 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for BINA

BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

Compound Libraries for BINA

BINA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BINA

M. Wt 454.56
Formula C30H30O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 866823-73-6
PubChem ID 9868580
InChI Key KMKBEESNZAPKMP-UHFFFAOYSA-N
Smiles CC1=C(C)C(C(C(C5CCCC5)C4)=O)=C4C=C1OCC2=CC(C3=CC=C(C(O)=O)C=C3)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BINA

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.46 100

Preparing Stock Solutions for BINA

The following data is based on the product molecular weight 454.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for BINA

Certificate of Analysis / Product Datasheet
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References for BINA

References are publications that support the biological activity of the product.

Bonnefous et al (2005) Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg.Med.Chem.Lett. 15 4354 PMID: 16046122

Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J.Pharmacol.Exp.Ther. 318 173 PMID: 16608916

Benneyworth et al (2007) A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol.Pharmacol. 72 477 PMID: 17526600


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Citations for BINA

Citations are publications that use Tocris products.

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Reviews for BINA

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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