LY 379268 disodium salt

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Cat.No. 5064 - LY 379268 disodium salt | C7H7NNa2O5
Description: Sodium salt of LY 379268 (Cat. No. 2453); selective group II mGlu receptor agonist
Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Sodium salt of LY 379268 (Cat. No. 2453), a highly selective group II mGlu receptor agonist.

Technical Data

M. Wt 231.11
Formula C7H7NNa2O5
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 10197984
InChI Key YASVRZWVUGJELU-MDASVERJSA-N
Smiles [H][C@]12[C@]([C@H]2[C@](O[Na])=O)([H])[C@@]([C@](O[Na])=O)(N)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 231.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.63 mL 43.27 mL
5 mM 0.87 mL 4.33 mL 8.65 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bond et al (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 273 PMID: 10515191

Bond et al (2000) Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 294 800 PMID: 10945827

Collado et al (2002) (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 45 3619 PMID: 12166935


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View all Glutamate (Metabotropic) Group II Receptor Agonists

Keywords: LY379268 disodium salt 2Na selective group II agonists Group Receptors mGlu2 mGluR2 mGlu3 mGluR3 Glutamate Metabotropic Glutamate (Metabotropic) Group II Receptors

Citations for LY 379268 disodium salt

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