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Submit ReviewL-CCG-l
Description: Potent group II mGlu agonist
Alternative Names: (2S,3S,4S)-CCG
Chemical Name: (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
Purity: ≥99% (HPLC)
Biological Activity for L-CCG-l
L-CCG-l is a potent group II metabotropic glutamate receptor agonist. More active than glutamate or (±)-trans-ACPD (Cat. No. 0187).
Technical Data for L-CCG-l
| M. Wt | 159.14 |
| Formula | C6H9NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 117857-93-9 |
| PubChem ID | 5310956 |
| InChI Key | GZOVEPYOCJWRFC-HZLVTQRSSA-N |
| Smiles | N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@]1([C@@](O)=O)[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-CCG-l
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 100 |
Preparing Stock Solutions for L-CCG-l
The following data is based on the product molecular weight 159.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.28 mL | 31.42 mL | 62.84 mL |
| 5 mM | 1.26 mL | 6.28 mL | 12.57 mL |
| 10 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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Product Datasheets for L-CCG-l
References for L-CCG-l
References are publications that support the biological activity of the product.
Brabet et al (1998) Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37 1043 PMID: 9833633
Hayashi et al (1992) Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 107 539 PMID: 1330184
Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213 PMID: 2692753
Wright and Schoepp (1996) Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus. Eur.J.Pharmacol. 297 275 PMID: 8666060
If you know of a relevant reference for L-CCG-l, please let us know.
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Keywords: L-CCG-l, L-CCG-l supplier, Potent, group, II, mGlur, agonists, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (2S,3S,4S)-CCG, (Metabotropic), 0333, Tocris Bioscience
4 Citations for L-CCG-l
Citations are publications that use Tocris products. Selected citations for L-CCG-l include:
Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Neuron 108 9993 PMID: 21628565
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Han et al (2015) Alleviation of kainic acid-induced brain barrier dysfunction by 4-o-methylhonokiol in in vitro and in vivo models. Biomed Res Int 2015 893163 PMID: 25688368
Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777
Do you know of a great paper that uses L-CCG-l from Tocris? Please let us know.
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