Glucocorticoid Receptors

Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3685 Corticosterone
Endogenous glucocorticoid
2007 Fluticasone propionate
Selective high affinity glucocorticoid receptor agonist
4116 GSK 9027
Glucocorticoid receptor agonist
4819 Methylprednisolone
Glucocorticoid receptor agonist
4115 Mometasone furoate
Synthetic corticosteroid; anti-inflammatory agent

Antagonists

Cat No Product Name / Activity
1479 Mifepristone
Glucocorticoid and progesterone receptor antagonist

Other

Cat No Product Name / Activity
2671 Budesonide
Synthetic glucocorticoid; anti-inflammatory and chemopreventive
1126 Dexamethasone
Anti-inflammatory glucocorticoid
4093 Hydrocortisone
Adrenal glucocorticoid; immunosuppressant

Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by GRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.

GRs are ubiquitously expressed and mediate a vast array of physiological functions. Glucocorticoids regulate carbohydrate, protein and fat metabolism, modulate immune responses through supression of chemokine and cytokine production and have critical roles in constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems. The human gene encoding the glucocorticoid receptor has been localized to 5q31-q32.

External sources of pharmacological information for Glucocorticoid Receptors :

    Literature for Glucocorticoid Receptors

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Immunology

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation
    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors
    Asthma

    Asthma Poster

    Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

    Depression

    Depression Poster

    Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

    Glucocorticoid Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human NR3C1 NM_001020825 P04150
    Mouse Nr3c1 NM_008173 P06537
    Rat Nr3c1 NM_012576 P06536