Mineralocorticoid Receptors

Mineralocorticoid receptors (MRs) are nuclear hormone receptors of the NR3C class, which also includes androgen, progesterone and glucocorticoid receptors. They can exist as homo- or heterodimers and are coupled to Hsp90 or HMGB proteins.

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Products
Background
Gene Data

Mineralocorticoid Receptor Agonists

Cat. No. Product Name / Activity
3685 Corticosterone
Endogenous glucocorticoid

Mineralocorticoid Receptor Antagonists

Cat. No. Product Name / Activity
2397 Eplerenone
Selective mineralocorticoid receptor antagonist
1672 RU 28318, potassium salt
Potent, selective mineralocorticoid receptor antagonist
2968 Spironolactone
Mineralocorticoid receptor antagonist

Mineralocorticoid receptors (MRs) are nuclear hormone receptors of the NR3C class, which also includes androgen, progesterone and glucocorticoid receptors. They can exist as homo- or heterodimers and are coupled to Hsp90 or HMGB proteins. The major signaling pathway used by MRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.

External sources of pharmacological information for Mineralocorticoid Receptors :

Mineralocorticoid Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human NR3C2 NM_000901 P08235
Mouse Nr3c2 NM_001083906 Q8VII8
Rat Nr3c2 NM_013131 P22199