Pricing Availability   Qty
Description: Endogenous glucocorticoid
Chemical Name: (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Purity: ≥99% (HPLC)
Citations (4)
Reviews (1)
Literature (1)

Biological Activity for Corticosterone

Corticosterone is an endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Compound Libraries for Corticosterone

Corticosterone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Corticosterone

M. Wt 346.46
Formula C21H30O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-22-6
PubChem ID 5753
Smiles [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Corticosterone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.65 100

Preparing Stock Solutions for Corticosterone

The following data is based on the product molecular weight 346.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.86 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Corticosterone

Certificate of Analysis / Product Datasheet
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References for Corticosterone

References are publications that support the biological activity of the product.

Lu et al (2006) International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol.Rev. 58 782 PMID: 17132855

If you know of a relevant reference for Corticosterone, please let us know.

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Keywords: Corticosterone, Corticosterone supplier, endogenous, glucocorticoid, receptors, mineralocorticoid, nuclear, steroid, hormone, Glucocorticoid, Receptor, Mineralocorticoid, 3685, Tocris Bioscience

4 Citations for Corticosterone

Citations are publications that use Tocris products. Selected citations for Corticosterone include:

Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483

Gang et al (2021) Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. J Neurochem 158 358-372 PMID: 33025573

Roshanak et al (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife 8 PMID: 31433293

Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625 PMID: 23056375

Do you know of a great paper that uses Corticosterone from Tocris? Please let us know.

Reviews for Corticosterone

Average Rating: 5 (Based on 1 Review.)

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works well.
By Anonymous on 03/29/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat adrenal medulla chromaffin cells

1 mM

PMID: 30567483
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.