Corticosterone

Pricing Availability Delivery Time Qty
Cat.No. 3685 - Corticosterone | C21H30O4 | CAS No. 50-22-6
Description: Endogenous glucocorticoid
Chemical Name: (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Compound Libraries

Corticosterone is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 346.46
Formula C21H30O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-22-6
PubChem ID 5753
InChI Key OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Smiles [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.65 100
ethanol 3.46 10

Preparing Stock Solutions

The following data is based on the product molecular weight 346.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.86 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lu et al (2006) International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol.Rev. 58 782 PMID: 17132855


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View all Glucocorticoid Receptor Agonists

Keywords: endogenous glucocorticoid receptors mineralocorticoid nuclear steroid hormone Glucocorticoid Receptor

1 Citation for Corticosterone

Citations are publications that use Tocris products. Selected citations for Corticosterone include:

Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625 PMID: 23056375


Do you know of a great paper that uses Corticosterone from Tocris? If so please let us know.

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Pathways for Corticosterone

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