Corticosterone

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Cat.No. 3685 - Corticosterone | C21H30O4 | CAS No. 50-22-6
Description: Endogenous glucocorticoid
Chemical Name: (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (5)

Biological Activity

Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Compound Libraries

Corticosterone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 346.46
Formula C21H30O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-22-6
PubChem ID 5753
InChI Key OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Smiles [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.65 100
ethanol 3.46 10

Preparing Stock Solutions

The following data is based on the product molecular weight 346.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.86 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lu et al (2006) International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol.Rev. 58 782 PMID: 17132855


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Keywords: Corticosterone, Corticosterone supplier, endogenous, glucocorticoid, receptors, mineralocorticoid, nuclear, steroid, hormone, Glucocorticoid, Receptor, Mineralocorticoid, 3685, Tocris Bioscience

2 Citations for Corticosterone

Citations are publications that use Tocris products. Selected citations for Corticosterone include:

Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483

Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625 PMID: 23056375


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Reviews for Corticosterone

Average Rating: 5 (Based on 1 Review.)

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works well.
By Anonymous on 03/29/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat adrenal medulla chromaffin cells

1 mM

PMID: 30567483
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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