GSK 9027

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Cat.No. 4116 - GSK 9027 | C27H19F4N3O2S | CAS No. 1229096-88-1
Description: Glucocorticoid receptor agonist
Chemical Name: N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Compound Libraries

GSK 9027 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 525.52
Formula C27H19F4N3O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1229096-88-1
PubChem ID 24882669
InChI Key DXBJGDVBQPEMOB-UHFFFAOYSA-N
Smiles FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 525.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.51 mL 19.03 mL
5 mM 0.38 mL 1.9 mL 3.81 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Yates et al (2010) Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 53 4531 PMID: 20469868


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Keywords: GSK 9027, supplier, gsk, GSK9027, glucocorticoid, receptors, agonists, Glucocorticoid, Receptor, Tocris Bioscience

Citations for GSK 9027

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