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Submit ReviewGlucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
Sold for research purposes under agreement from Pfizer Inc.
Methylprednisolone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
M. Wt | 374.47 |
Formula | C22H30O5 |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 83-43-2 |
PubChem ID | 6741 |
InChI Key | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
Smiles | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.45 | 100 |
The following data is based on the product molecular weight 374.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.67 mL | 13.35 mL | 26.7 mL |
5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
References are publications that support the biological activity of the product.
Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141 PMID: 18354017
Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes. J.Neurosci. 29 2022 PMID: 19228956
If you know of a relevant reference for Methylprednisolone, please let us know.
Keywords: Methylprednisolone, Methylprednisolone supplier, Glucocorticoids, receptors, GR, agonists, anti-inflammatory, antioxidants, apoptosis, antiapoptosis, antiapoptotic, oligodendrocytes, Bcl-xL, Bcl-2, GR/STAT5, Neuroprotective, injury, Glucocorticoid, Receptor, Family, 4819, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.