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Submit ReviewMethylprednisolone
Description: Glucocorticoid receptor agonist
Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Purity: ≥99% (HPLC)
Biological Activity for Methylprednisolone
Methylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Methylprednisolone
Methylprednisolone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Methylprednisolone
| M. Wt | 374.47 |
| Formula | C22H30O5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 83-43-2 |
| PubChem ID | 6741 |
| InChI Key | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Methylprednisolone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.45 | 100 |
Preparing Stock Solutions for Methylprednisolone
The following data is based on the product molecular weight 374.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.35 mL | 26.7 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets for Methylprednisolone
References for Methylprednisolone
References are publications that support the biological activity of the product.
Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141 PMID: 18354017
Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes. J.Neurosci. 29 2022 PMID: 19228956
If you know of a relevant reference for Methylprednisolone, please let us know.
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Keywords: Methylprednisolone, Methylprednisolone supplier, Glucocorticoids, receptors, GR, agonists, anti-inflammatory, antioxidants, apoptosis, antiapoptosis, antiapoptotic, oligodendrocytes, Bcl-xL, Bcl-2, GR/STAT5, Neuroprotective, injury, Glucocorticoid, Receptor, Family, 4819, Tocris Bioscience
Citations for Methylprednisolone
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Reviews for Methylprednisolone
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Anti-inflammatory effects in neural tissue.
By
Luiz Alexandre Magno on 02/17/2022
Assay Type: In Vivo
Species: Rat
This anti-inflammatory decreases inflammation in neural tissue. Pretreatment with this drug is able to decrease the proliferation of glial cells (see the image, right side). This experimental model is useful to create comparisons with new drugs to be tested.
Its is very important to perform a time response curve to get the best results.
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