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Description: Glucocorticoid receptor agonist
Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Purity: ≥99% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for Methylprednisolone

Methylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Methylprednisolone

Methylprednisolone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Methylprednisolone

M. Wt 374.47
Formula C22H30O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 83-43-2
PubChem ID 6741
Smiles O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Methylprednisolone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.45 100

Preparing Stock Solutions for Methylprednisolone

The following data is based on the product molecular weight 374.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.35 mL 26.7 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for Methylprednisolone

Certificate of Analysis / Product Datasheet
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References for Methylprednisolone

References are publications that support the biological activity of the product.

Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141 PMID: 18354017

Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes. J.Neurosci. 29 2022 PMID: 19228956

If you know of a relevant reference for Methylprednisolone, please let us know.

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Keywords: Methylprednisolone, Methylprednisolone supplier, Glucocorticoids, receptors, GR, agonists, anti-inflammatory, antioxidants, apoptosis, antiapoptosis, antiapoptotic, oligodendrocytes, Bcl-xL, Bcl-2, GR/STAT5, Neuroprotective, injury, Glucocorticoid, Receptor, Family, 4819, Tocris Bioscience

Citations for Methylprednisolone

Citations are publications that use Tocris products.

Currently there are no citations for Methylprednisolone. Do you know of a great paper that uses Methylprednisolone from Tocris? Please let us know.

Reviews for Methylprednisolone

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Anti-inflammatory effects in neural tissue.
By Luiz Alexandre Magno on 02/17/2022
Assay Type: In Vivo
Species: Rat

This anti-inflammatory decreases inflammation in neural tissue. Pretreatment with this drug is able to decrease the proliferation of glial cells (see the image, right side). This experimental model is useful to create comparisons with new drugs to be tested.

Its is very important to perform a time response curve to get the best results.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.