Methylprednisolone
Biological Activity
Glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
Methylprednisolone is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 374.47 |
| Formula | C22H30O5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 83-43-2 |
| PubChem ID | 6741 |
| InChI Key | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.45 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 374.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.35 mL | 26.7 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141 PMID: 18354017
Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J.Neurosci. 29 2022 PMID: 19228956
If you know of a relevant reference for Methylprednisolone, please let us know.
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Keywords: Glucocorticoids receptors GR agonists anti-inflammatory antioxidants apoptosis antiapoptosis antiapoptotic oligodendrocytes Bcl-xL Bcl-2 GR/STAT5 Neuroprotective injury Glucocorticoid Receptor
Citations for Methylprednisolone
Citations are publications that use Tocris products.
Currently there are no citations for Methylprednisolone. Do you know of a great paper that uses Methylprednisolone from Tocris? If so please let us know.
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