Progesterone Receptors

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4833 Levonorgestrel
Synthetic progesterone analog
4115 Mometasone furoate
Synthetic corticosteroid; anti-inflammatory agent
2835 Progesterone
Endogenous progesterone receptor agonist

Antagonists

Cat No Product Name / Activity
1479 Mifepristone
Progesterone and glucocorticoid receptor antagonist

Inhibitors

Cat No Product Name / Activity
6285 Megestrol Acetate
Synthetic progesterone analog

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.

Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition, progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

External sources of pharmacological information for Progesterone Receptors :

    Literature for Progesterone Receptors

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
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    • Invasion and Metastasis
    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors

    Progesterone Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human PGR NM_000926 P06401
    Mouse Pgr NM_008829 Q00175
    Rat Pgr NM_022847 Q62629