D3 Receptors

D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0706 7-Hydroxy-DPAT hydrobromide
Dopamine agonist (D3 ≥ D2 < > D4)
1243 (+)-PD 128907 hydrochloride
D3 agonist (D3 ≥ D2 > D4)
4174 Pramipexole dihydrochloride
Selective D3 agonist
3896 Rotigotine hydrochloride
Dopamine D2/D3 agonist

Antagonists

Cat No Product Name / Activity
1847 Eticlopride hydrochloride
D3 antagonist (D3 > D2)
3940 GSK 789472 hydrochloride
D3 antagonist. Also D2 partial agonist
1347 Nafadotride
Highly potent, preferential D3 antagonist
2635 NGB 2904
Potent and selective D3 antagonist
3887 PG 01037 dihydrochloride
D3 receptor selective antagonist
3355 PNU 177864 hydrochloride
Highly selective D3 antagonist
4207 SB 277011A dihydrochloride
Selective D3 antagonist
1357 U 99194 maleate
Potent, selective D3 antagonist

D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion and have a possible role in cognition and emotion. The human D3 receptor gene has been localized to chromosome 3 (3q13.3).

External sources of pharmacological information for D3 Receptors :

Literature for D3 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

D3 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human DRD3 NM_033660 P35462
Mouse Drd3 NM_007877 P30728
Rat Drd3 NM_017140 P19020