Pramipexole dihydrochloride

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Cat.No. 4174 - Pramipexole dihydrochloride | C10H17N3S.2HCl | CAS No. 104632-25-9
Description: Selective D3 agonist
Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.

Compound Libraries

Pramipexole dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 284.25
Formula C10H17N3S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 104632-25-9
PubChem ID 119569
InChI Key QMNWXHSYPXQFSK-KLXURFKVSA-N
Smiles NC(S2)=NC1=C2C[C@@H](NCCC)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.43 100
water 28.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 284.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.18 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mierau et al (1995) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur.J.Pharmacol. 290 29 PMID: 7664822


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Keywords: dopamine D3 agonists Parkinsons Disease antiparkinson parkinson's dopaminergic D3 Receptors

2 Citations for Pramipexole dihydrochloride

Citations are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. J Exp Bot 11 2057 PMID: 26649942

Bonito-Oliva et al (2014) A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions. Front Behav Neurosci 8 290 PMID: 25221486


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Literature in this Area

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Pathways for Pramipexole dihydrochloride

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