Pramipexole dihydrochloride

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Cat.No. 4174 - Pramipexole dihydrochloride | C10H17N3S.2HCl | CAS No. 104632-25-9
Description: Selective D3 agonist
Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (5)

Biological Activity

Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.

Compound Libraries

Pramipexole dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 284.25
Formula C10H17N3S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 104632-25-9
PubChem ID 119569
InChI Key QMNWXHSYPXQFSK-KLXURFKVSA-N
Smiles NC(S2)=NC1=C2C[C@@H](NCCC)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.43 100
DMSO 28.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 284.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.18 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References

References are publications that support the biological activity of the product.

Mierau et al (1995) Pramipexole binding and activation of cloned and expressed DA D2, D3 and D4 receptors. Eur.J.Pharmacol. 290 29 PMID: 7664822


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Keywords: Pramipexole dihydrochloride, Pramipexole dihydrochloride supplier, dopamine, D3, agonists, Parkinsons, Disease, antiparkinson, parkinson's, dopaminergic, Receptors, 4174, Tocris Bioscience

2 Citations for Pramipexole dihydrochloride

Citations are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation. J Exp Bot 11 2057 PMID: 26649942

Bonito-Oliva et al (2014) A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions. Front Behav Neurosci 8 290 PMID: 25221486


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Reviews for Pramipexole dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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