Eticlopride hydrochloride

Pricing Availability   Qty
Description: D2 and D3 antagonist (D3 > D2)
Alternative Names: (-)-Eticlopride
Chemical Name: 3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
Purity: ≥99% (HPLC)
Citations (7)
Reviews (1)
Literature (4)

Biological Activity for Eticlopride hydrochloride

Eticlopride hydrochloride is a selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Antipsychotic.

Technical Data for Eticlopride hydrochloride

M. Wt 377.31
Formula C17H25ClN2O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 97612-24-3
PubChem ID 57266
Smiles O=C(C2=C(OC)C(Cl)=CC(CC)=C2O)NC[C@@H]1CCCN1CC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Eticlopride hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 37.73 100

Preparing Stock Solutions for Eticlopride hydrochloride

The following data is based on the product molecular weight 377.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for Eticlopride hydrochloride

References for Eticlopride hydrochloride

References are publications that support the biological activity of the product.

Hall et al (1985) Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for DA-D2 receptors in the rat brain. Eur.J.Pharmacol. 111 191 PMID: 4018125

Giuliani and Ferrari (1997) Involvement of DA receptors in the antipsychotic profile of (-) eticlopride. Physiol.Behav. 61 563 PMID: 9108576

Claytor et al (2006) The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol.Biochem.Behav. 83 456 PMID: 16631246

If you know of a relevant reference for Eticlopride hydrochloride, please let us know.

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Keywords: Eticlopride hydrochloride, Eticlopride hydrochloride supplier, Selective, antagonists, D3, D2, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, (-)-Eticlopride, Non-selective, 1847, Tocris Bioscience

7 Citations for Eticlopride hydrochloride

Citations are publications that use Tocris products. Selected citations for Eticlopride hydrochloride include:

Dorst et al (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun 11 5113 PMID: 33037215

Cassar et al (2015) A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila. J Ginseng Res 24 197 PMID: 25158689

Burgess et al (2010) DArgic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851

Zhao et al (2014) Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats. Neuropsychopharmacology 38 256 PMID: 25379005

Do you know of a great paper that uses Eticlopride hydrochloride from Tocris? Please let us know.

Reviews for Eticlopride hydrochloride

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Effects of eticlopride on cue-induced reinstatement of food seeking.
By Kevin Ball on 01/22/2019
Assay Type: In Vivo
Species: Rat

At a dose that did not alter responding during food self-administration (6.0 micrograms/kg), systemic injections of eticlopride significantly increased responding during cue-induced reinstatement of food seeking tests.

PMID: 21497172
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