Eticlopride hydrochloride

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Cat.No. 1847 - Eticlopride hydrochloride | C17H25ClN2O3.HCl | CAS No. 97612-24-3
Description: Selective D2/D3 antagonist
Alternative Names: (-)-Eticlopride
Chemical Name: 3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Antipsychotic.

Technical Data

M. Wt 377.31
Formula C17H25ClN2O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 97612-24-3
PubChem ID 57266
InChI Key HFJFXXDHVWLIKX-YDALLXLXSA-N
Smiles O=C(C2=C(OC)C(Cl)=CC(CC)=C2O)NC[C@@H]1CCCN1CC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 377.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Hall et al (1985) Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain. Eur.J.Pharmacol. 111 191 PMID: 4018125

Giuliani and Ferrari (1997) Involvement of dopamine receptors in the antipsychotic profile of (-) eticlopride. Physiol.Behav. 61 563 PMID: 9108576

Claytor et al (2006) The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol.Biochem.Behav. 83 456 PMID: 16631246


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Keywords: Eticlopride hydrochloride, Eticlopride hydrochloride supplier, Selective, antagonists, D3, D2, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, (-)-Eticlopride, Non-selective, 1847, Tocris Bioscience

6 Citations for Eticlopride hydrochloride

Citations are publications that use Tocris products. Selected citations for Eticlopride hydrochloride include:

Jensen (2015) Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PLoS One 10 e0146154 PMID: 26717015

Tønnesen et al (2011) Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS One 6 e17560 PMID: 21394212

Cassar et al (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. J Ginseng Res 24 197 PMID: 25158689

Burgess et al (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851

Zhao et al (2014) Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats. Neuropsychopharmacology 38 256 PMID: 25379005

Kramar et al (2014) Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. Int J Neuropsychopharmacol 39 1645 PMID: 24442095


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