D1 and D5 Receptors

D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.

Gene Data


Cat No Product Name / Activity
1534 A 68930 hydrochloride
Potent, selective D1-like agonist
1701 A 77636 hydrochloride
Potent and selective D1-like agonist; orally active
2073 (R)-(-)-Apomorphine hydrochloride
Dopamine agonist; non-subtype-selective
1249 CY 208-243
Selective D1-like agonist
0884 Dihydrexidine hydrochloride
Selective D1-like agonist
3548 Dopamine hydrochloride
Endogenous agonist at dopamine D1-5 receptors
1659 Fenoldopam hydrochloride
Selective D1-like partial agonist
3992 NPEC-caged-dopamine
Caged version of dopamine (Cat. No. 3548)
0922 SKF 38393 hydrobromide
Selective D1-like agonist
1662 SKF 77434 hydrobromide
Selective D1-like partial agonist
1447 SKF 81297 hydrobromide
D1 agonist
5719 SKF 82958 hydrobromide
D1 agonist
2075 SKF 83822 hydrobromide
Selective D1-like agonist
2074 SKF 83959 hydrobromide
D1-like partial agonist


Cat No Product Name / Activity
1674 LE 300
Potent and selective D1 antagonist
0925 SCH 23390 hydrochloride
Standard selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
2299 SCH 39166 hydrobromide
High affinity D1-like antagonist
1586 SKF 83566 hydrobromide
Potent, selective D1-like antagonist

D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).

External sources of pharmacological information for D1 and D5 Receptors :

    Literature for D1 and D5 Receptors

    Tocris offers the following scientific literature for D1 and D5 Receptors to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Dopamine Receptors

    Dopamine Receptors Scientific Review

    Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.


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    D1 and D5 Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    D1 Human DRD1 NM_000794 P21728
    Mouse Drd1a NM_010076 Q61616
    Rat Drd1a NM_012546 P18901
    D5 Human DRD5 NM_000798 P21918
    Mouse Drd5 NM_013503 Q8BLD9
    Rat Drd5 NM_012768 P25115