D1 and D5 Receptors

D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1534 A 68930 hydrochloride
Potent, selective D1-like agonist
1701 A 77636 hydrochloride
Potent, selective D1-like agonist. Orally active
2073 (R)-(-)-Apomorphine hydrochloride
Dopamine agonist; non-subtype-selective
1249 CY 208-243
Selective D1-like agonist
0884 Dihydrexidine hydrochloride
Selective D1-like agonist
3548 Dopamine hydrochloride
Endogenous agonist at dopamine D1-5 receptors
1659 Fenoldopam hydrochloride
Selective D1-like partial agonist
3992 NPEC-caged-dopamine
Caged version of dopamine (Cat. No. 3548)
0922 SKF 38393 hydrobromide
Selective D1-like agonist
1662 SKF 77434 hydrobromide
Selective D1-like partial agonist
1447 SKF 81297 hydrobromide
D1 agonist
5719 SKF 82958 hydrobromide
D1 agonist
2075 SKF 83822 hydrobromide
Selective D1-like agonist
2074 SKF 83959 hydrobromide
D1-like partial agonist

Antagonists

Cat No Product Name / Activity
1674 LE 300
Potent and selective dopamine D1 antagonist
0925 SCH 23390 hydrochloride
Standard selective D1-like antagonist; also 5-HT2C and 5-HT1C agonist and Kir3 channel blocker
2299 SCH 39166 hydrobromide
High affinity D1/D5 receptor antagonist
1586 SKF 83566 hydrobromide
Potent, selective D1-like antagonist

D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).

Literature for D1 and D5 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

D1 and D5 Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
D1 Human DRD1 NM_000794 P21728
Mouse Drd1a NM_010076 Q61616
Rat Drd1a NM_012546 P18901
D5 Human DRD5 NM_000798 P21918
Mouse Drd5 NM_013503 Q8BLD9
Rat Drd5 NM_012768 P25115