NGB 2904

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Cat.No. 2635 - NGB 2904 | C28H29Cl2N3O.HCl | CAS No. 189061-11-8
Description: Potent and selective D3 antagonist
Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Compound Libraries

NGB 2904 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 530.92
Formula C28H29Cl2N3O.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 189061-11-8
PubChem ID 19366304
InChI Key PFIWYJNBKGCVFM-UHFFFAOYSA-N
Smiles Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNC(=O)C2=CC=C3C(CC4=CC=CC=C34)=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.27 25
ethanol 2.65 5

Preparing Stock Solutions

The following data is based on the product molecular weight 530.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 7.53 mL 37.67 mL 75.34 mL
1.25 mM 1.51 mL 7.53 mL 15.07 mL
2.5 mM 0.75 mL 3.77 mL 7.53 mL
12.5 mM 0.15 mL 0.75 mL 1.51 mL

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References

References are publications that support the biological activity of the product.

Yuan et al (1998) NGB 2904 and NGB 2849: two highly selective DA D3 receptor antagonists. Bioorg.Med.Chem.Lett. 8 2715 PMID: 9873609

Xi et al (2006) The novel DA D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31 1393 PMID: 16205781

Pritchard et al (2007) The DA D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 86 718 PMID: 17408730


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Keywords: NGB 2904, NGB 2904 supplier, Potent, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, NGB2904, 2635, Tocris Bioscience

1 Citation for NGB 2904

Citations are publications that use Tocris products. Selected citations for NGB 2904 include:

Axel et al (2010) Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and DA D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology 35 1464 PMID: 20200509


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