SB 277011A dihydrochloride

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Cat.No. 4207 - SB 277011A dihydrochloride | C28H30N4O.2HCl | CAS No. 1226917-67-4
Description: Selective D3 antagonist
Chemical Name: N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M. Wt 511.49
Formula C28H30N4O.2HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1226917-67-4
PubChem ID 75358288
InChI Key HEZIOTGUXSPDAK-UHFFFAOYSA-N
Smiles O=C(N[C@@H]3CC[C@@H](CCN4CC(C=CC(C#N)=C5)=C5CC4)CC3)C1=C2C(C=CC=C2)=NC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.57 50
water 2.56 5

Preparing Stock Solutions

The following data is based on the product molecular weight 511.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.55 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Reavill et al (2000) Pharmacological actions of a novel, high-affinity, and selective human dopamine D3 receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 294 1154 PMID: 10945872

Stemp et al (2000) esign and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective dopamine D3 receptor antagonist with high oral bioavailability and J.Med.Chem. 43 1878 PMID: 10794704


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Keywords: SB277011A dihydrochloride dopamine dopaminergic receptors antagonists selective d3 D3 Receptors

1 Citation for SB 277011A dihydrochloride

Citations are publications that use Tocris products. Selected citations for SB 277011A dihydrochloride include:

Chen et al (2013) Electroacupuncture reduces cocaine-induced seizures and mortality in mice. Nat Neurosci 2013 134610 PMID: 23690833


Do you know of a great paper that uses SB 277011A dihydrochloride from Tocris? If so please let us know.

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