SB 277011A dihydrochloride

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Description: Selective D3 antagonist
Chemical Name: N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity for SB 277011A dihydrochloride

SB 277011A dihydrochloride is a selective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for SB 277011A dihydrochloride

M. Wt 511.49
Formula C28H30N4O.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1226917-67-4
PubChem ID 75358288
InChI Key HEZIOTGUXSPDAK-UHFFFAOYSA-N
Smiles O=C(N[C@@H]3CC[C@@H](CCN4CC(C=CC(C#N)=C5)=C5CC4)CC3)C1=C2C(C=CC=C2)=NC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 277011A dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.57 50

Preparing Stock Solutions for SB 277011A dihydrochloride

The following data is based on the product molecular weight 511.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.91 mL 19.55 mL 39.1 mL
2.5 mM 0.78 mL 3.91 mL 7.82 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets for SB 277011A dihydrochloride

Certificate of Analysis / Product Datasheet
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References for SB 277011A dihydrochloride

References are publications that support the biological activity of the product.

Reavill et al (2000) Pharmacological actions of a novel, high-affinity, and selective human DA D3 receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 294 1154 PMID: 10945872

Stemp et al (2000) Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective DA D3 receptor antagonist with high oral bioavailability and CNS pe J.Med.Chem. 43 1878 PMID: 10794704


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Keywords: SB 277011A dihydrochloride, SB 277011A dihydrochloride supplier, SB277011A, dihydrochloride, dopamine, dopaminergic, receptors, antagonists, selective, d3, D3, Receptors, 4207, Tocris Bioscience

1 Citation for SB 277011A dihydrochloride

Citations are publications that use Tocris products. Selected citations for SB 277011A dihydrochloride include:

Chen et al (2013) Electroacupuncture reduces cocaine-induced seizures and mortality in mice. Nat Neurosci 2013 134610 PMID: 23690833


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Reviews for SB 277011A dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.