D2 Receptors

D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.

Gene Data


Cat No Product Name / Activity
5584 Aripiprazole
High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
2759 B-HT 920
D2 agonist; also α2-adrenoceptor agonist and 5-HT3 antagonist
3940 GSK 789472 hydrochloride
D2 partial agonist; D3 antagonist
3896 Rotigotine hydrochloride
Dopamine D2/D3 agonist
2773 Sumanirole maleate
Selective D2 agonist

Partial Agonists

Cat No Product Name / Activity
6171 MLS 1547
G protein-biased D2 receptor partial agonist


Cat No Product Name / Activity
5858 Droperidol
D2 receptor antagonist
1003 L-741,626
High affinity D2 antagonist
2495 Melperone hydrochloride
D2/5-HT2A receptor antagonist; neuroleptic
4349 Olanzapine
5-HT2A/D2 antagonist; atypical antipsychotic
4493 Paliperidone
Atypical antipsychotic; 5-HT2A and D2 antagonist
3287 Prochlorperazine dimaleate
D2 receptor antagonist. Also 5-HT3 and nAChR antagonist
4735 Quetiapine hemifumarate
5-HT2/D2 antagonist; atypical antipsychotic
2865 Risperidone
D2 antagonist. Also 5-HT2A antagonist
0775 (+)-UH 232 maleate
D2 autoreceptor antagonist. Also D3 partial agonist
3085 Ziprasidone hydrochloride
5-HT2A/D2 antagonist; atypical antipsychotic
3996 Zotepine
5-HT2A/D2 antagonist; atypical antipsychotic


Cat No Product Name / Activity
5041 PAOPA
Dopamine D2 receptor allosteric modulator

D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The human D2 receptor gene has been localized to chromosome 11 (11q22-23).

External sources of pharmacological information for D2 Receptors :

Literature for D2 Receptors

Tocris offers the following scientific literature for D2 Receptors to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.


Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

D2 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human DRD2 NM_000795 P14416
Mouse Drd2 NM_010077 P61168
Rat Drd2 NM_012547 P61169