(+)-PD 128907 hydrochloride

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Cat.No. 1243 - (+)-PD 128907 hydrochloride | C14H19NO3.HCl | CAS No. 300576-59-4
Description: High affinity D3 agonist (D3 ≥ D2 > D4)
Chemical Name: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
Purity: ≥99% (HPLC)
Citations (9)

Biological Activity

High affinity D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.

Technical Data

M. Wt 285.77
Formula C14H19NO3.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 300576-59-4
PubChem ID 11957668
Smiles CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Bristow et al (1996) The behavioural and neurochemical profile of the putative DA D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285 PMID: 8783203

Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective DA D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355 PMID: 8531103

Witkin et al (1998) Atypical antipsychotic-like effects of the DA D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1 PMID: 9741997

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9 Citations for (+)-PD 128907 hydrochloride

Citations are publications that use Tocris products. Selected citations for (+)-PD 128907 hydrochloride include:

Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483

Shin et al (2018) Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction. Neuron 97 195 PMID: 29276054

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Basso et al (2005) Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30 1257 PMID: 15688083

Zhang et al (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the DA D1 and D3 receptors. J Neurosci 24 3344 PMID: 15056714

Clemens and Hochman (2004) Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337 PMID: 15601940

Cote and Kuzhikandathil (2015) Chronic lev. treatment alters expression and function of DA D3 receptor in the MPTP/p mouse model of Parkinson's disease. J Neurosci 585 33 PMID: 25445374

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

Marcellino et al (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Neurosci Lett 283 26016 PMID: 18644790

Do you know of a great paper that uses (+)-PD 128907 hydrochloride from Tocris? Please let us know.

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