(+)-PD 128907 hydrochloride

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Cat.No. 1243 - (+)-PD 128907 hydrochloride | C14H19NO3.HCl | CAS No. 300576-59-4
Description: D3 agonist (D3 ≥ D2 > D4)
Chemical Name: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

Potent D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.

Technical Data

M. Wt 285.77
Formula C14H19NO3.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 300576-59-4
PubChem ID 11957668
InChI Key DCFXOTRONMKUJB-QMDUSEKHSA-N
Smiles CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 285.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.5 mL 34.99 mL
5 mM 0.7 mL 3.5 mL 7 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bristow et al (1996) The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285 PMID: 8783203

Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355 PMID: 8531103

Witkin et al (1998) Atypical antipsychotic-like effects of the dopamine D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1 PMID: 9741997


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Keywords: (+)-PD 128907 hydrochloride, supplier, D3, agonists, D2, D4, Dopamine, Receptors, dopaminergic, (+)-PD128907, hydrochloride, PD128907, D3, Receptors, D3, Receptors, Tocris Bioscience

6 Citations for (+)-PD 128907 hydrochloride

Citations are publications that use Tocris products. Selected citations for (+)-PD 128907 hydrochloride include:

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Marcellino et al (2008) Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Neurosci Lett 283 26016 PMID: 18644790

Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842 PMID: 17923483

Zhang et al (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 24 3344 PMID: 15056714

Clemens and Hochman (2004) Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337 PMID: 15601940

Cote and Kuzhikandathil (2015) Chronic levodopa treatment alters expression and function of dopamine D3 receptor in the MPTP/p mouse model of Parkinson's disease. J Neurosci 585 33 PMID: 25445374


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