(+)-PD 128907 hydrochloride

Pricing Availability   Qty
Description: High affinity D3 agonist (D3 ≥ D2 > D4)
Chemical Name: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
Purity: ≥98% (HPLC)
Citations (9)
Literature (3)

Biological Activity for (+)-PD 128907 hydrochloride

(+)-PD 128907 hydrochloride is a high affinity D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.

Technical Data for (+)-PD 128907 hydrochloride

M. Wt 285.77
Formula C14H19NO3.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 300576-59-4
PubChem ID 11957668
Smiles CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (+)-PD 128907 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 2.86 10

Preparing Stock Solutions for (+)-PD 128907 hydrochloride

The following data is based on the product molecular weight 285.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.99 mL 174.97 mL 349.93 mL
0.5 mM 7 mL 34.99 mL 69.99 mL
1 mM 3.5 mL 17.5 mL 34.99 mL
5 mM 0.7 mL 3.5 mL 7 mL

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Product Datasheets for (+)-PD 128907 hydrochloride

Certificate of Analysis / Product Datasheet
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References for (+)-PD 128907 hydrochloride

References are publications that support the biological activity of the product.

Bristow et al (1996) The behavioural and neurochemical profile of the putative DA D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285 PMID: 8783203

Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective DA D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355 PMID: 8531103

Witkin et al (1998) Atypical antipsychotic-like effects of the DA D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1 PMID: 9741997

If you know of a relevant reference for (+)-PD 128907 hydrochloride, please let us know.

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9 Citations for (+)-PD 128907 hydrochloride

Citations are publications that use Tocris products. Selected citations for (+)-PD 128907 hydrochloride include:

Marcellino et al (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Neurosci Lett 283 26016 PMID: 18644790

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

Cote and Kuzhikandathil (2015) Chronic lev. treatment alters expression and function of DA D3 receptor in the MPTP/p mouse model of Parkinson's disease. J Neurosci 585 33 PMID: 25445374

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Do you know of a great paper that uses (+)-PD 128907 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.