Dopamine Transporters

Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4357 Bicifadine hydrochloride
Noradrenalin, 5-HT and dopamine re-uptake inhibitor
0918 3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride
Potent dopamine uptake inhibitor
2831 Bupropion hydrochloride
Non-selective inhibitor of dopamine and noradrenalin transporters
2833 Cocaine hydrochloride
Inhibitor of monoamine transporters
0917 3-CPMT
Dopamine uptake inhibitor
4798 (S)-Duloxetine hydrochloride
Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
0513 GBR 12783 dihydrochloride
Potent, selective dopamine uptake inhibitor
0421 GBR 12909 dihydrochloride
Selective DA uptake inhibitor. Also σ ligand
0514 GBR 12935 dihydrochloride
Selective dopamine uptake inhibitor
0420 GBR 13069 dihydrochloride
Potent dopamine uptake inhibitor
1588 Indatraline hydrochloride
Potent dopamine uptake inhibitor; also inhibits 5-HT and noradrenalin uptake
4351 JHW 007 hydrochloride
High affinity dopamine uptake inhibitor
2148 (±)-McN 5652
Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro
3027 (±)-MDMA hydrochloride
Inhibitor of dopamine and 5-HT uptake; hallucinogenic
4443 Mephedrone hydrochloride
Inhibits synaptosomal dopamine and 5-HT uptake
1812 Threo-methylphenidate hydrochloride
Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
6131 (R)-Modafinil
Dopamine uptake inhibitor
1992 Nomifensine
Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
2742 Reserpine
Inhibitor of vesicular monoamine transport
1497 Rimcazole dihydrochloride
DAT inhibitor. Also σ2 antagonist
2175 Tetrabenazine
Potent inhibitor of vesicular monoamine transport; depletes dopamine stores

Other

Cat No Product Name / Activity
5200 FFN 102 mesylate
Selective fluorescent substrate of DAT and VMAT2

Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine, adrenalin and noradrenalin from the synaptic cleft, terminating the neurotransmitter signal.

Dopamine transporters can also mediate an outward efflux and it has been suggested that inward and outward transport are independently regulated. Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. There is evidence to support the role of dopamine transporters in attention deficit disorder, bipolar disorder, clinical depression and alcoholism.

External sources of pharmacological information for Dopamine Transporters :

    Literature for Dopamine Transporters

    Neurodegeneration

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    • Alzheimer's disease
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    Dopamine Receptors

    Dopamine Receptors Scientific Review

    Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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    Dopamine Transporter Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human SLC6A3 NM_001044 Q01959
    Mouse Slc6a3 NM_010020 Q61327
    Rat Slc6a3 NM_012694 P23977