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Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine.
|Cat. No.||Product Name / Activity|
|Noradrenalin, 5-HT and dopamine re-uptake inhibitor|
|0918||3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride|
|Potent dopamine uptake inhibitor|
|Non-selective inhibitor of dopamine and noradrenalin transporters|
|Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake|
|0513||GBR 12783 dihydrochloride|
|Potent and selective DA uptake inhibitor|
|0421||GBR 12909 dihydrochloride|
|Selective DA uptake inhibitor; also σ ligand|
|0514||GBR 12935 dihydrochloride|
|Selective dopamine uptake inhibitor|
|Potent dopamine uptake inhibitor; also inhibits 5-HT and noradrenalin uptake|
|4351||JHW 007 hydrochloride|
|High affinity dopamine uptake inhibitor|
|Inhibitor of dopamine and 5-HT uptake; hallucinogenic|
|Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant|
|Dopamine uptake inhibitor|
|Potent noradrenalin and dopamine uptake inhibitor. Antidepressant|
|Inhibitor of vesicular monoamine transport|
|DAT inhibitor. Also σ2 antagonist|
|Potent inhibitor of vesicular monoamine transport; depletes dopamine stores|
|Cat. No.||Product Name / Activity|
|Promotes endocytosis and oligomerization of DAT; also Ack1 inhibitor|
|5200||FFN 102 mesylate|
|Selective fluorescent substrate of DAT and VMAT2|
Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine, adrenalin and noradrenalin from the synaptic cleft, terminating the neurotransmitter signal.
Dopamine transporters can also mediate an outward efflux and it has been suggested that inward and outward transport are independently regulated. Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. There is evidence to support the role of dopamine transporters in attention deficit disorder, bipolar disorder, clinical depression and alcoholism.
Tocris offers the following scientific literature for Dopamine Transporters to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.