Rotigotine hydrochloride

Pricing Availability   Qty
Description: D2 and D3 agonist
Alternative Names: N 0923
Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity for Rotigotine hydrochloride

Rotigotine hydrochloride is a dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.

Compound Libraries for Rotigotine hydrochloride

Rotigotine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rotigotine hydrochloride

M. Wt 351.93
Formula C19H25NOS.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 125572-93-2
PubChem ID 59226
InChI Key CEXBONHIOKGWNU-NTISSMGPSA-N
Smiles CCCN(CCC3=CC=CS3)[C@H]2CCC1=C(O)C=CC=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rotigotine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.19 100

Preparing Stock Solutions for Rotigotine hydrochloride

The following data is based on the product molecular weight 351.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.41 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for Rotigotine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Rotigotine hydrochloride

References are publications that support the biological activity of the product.

Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73 PMID: 18704368

Belluzzi et al (2004) N-0923, a selective DA D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.Disord. 9 147 PMID: 7910948


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Keywords: Rotigotine hydrochloride, Rotigotine hydrochloride supplier, D2, D3, dopamine, agonists, receptor, N0923, parkinson's, parkinsons, N, 0923, Receptors, 3896, Tocris Bioscience

1 Citation for Rotigotine hydrochloride

Citations are publications that use Tocris products. Selected citations for Rotigotine hydrochloride include:

Fernández-Dueñas et al (2013) DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. J Exp Clin Cancer Res 63 42 PMID: 23619397


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Reviews for Rotigotine hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Dopamine Receptors Scientific Review

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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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