D4 Receptors

D4 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3 and D5. They are located primarily in the frontal cortex, midbrain, amygdala and the cardiovascular system. A role in cognition and emotion has been proposed.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4552 A 412997 dihydrochloride
Selective D4 agonist
2214 ABT 724 trihydrochloride
Potent, selective D4 partial agonist; proerectile
1065 PD 168077 maleate
High affinity, selective D4 agonist
2329 Ro 10-5824 dihydrochloride
Selective D4 receptor partial agonist
4380 WAY 100635 maleate
Dopamine D4 agonist. Also 5-HT1A silent antagonist

Antagonists

Cat No Product Name / Activity
2645 Fananserin
D4 antagonist. Also 5-HT2A antagonist
1004 L-741,742 hydrochloride
Highly selective D4 antagonist
1002 L-745,870 trihydrochloride
Highly selective D4 antagonist
3529 PD 168568 dihydrochloride
Potent and selective D4 antagonist
2735 PNU 96415E
D4 and 5-HT2A antagonist; antipsychotic
4185 Sonepiprazole
Selective D4 receptor antagonist

Ligands

Cat No Product Name / Activity
3298 NGD 94-1
Selective D4 receptor ligand

D4 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3 and D5. They are located primarily in the frontal cortex, midbrain, amygdala and the cardiovascular system. The function of the D4 receptor is unknown, although a role in cognition and emotion has been proposed. The human D4 receptor gene has been localized to chromosome 11 (11q15.5).

External sources of pharmacological information for D4 Receptors :

Literature for D4 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

D4 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human DRD4 NM_000797 P21917
Mouse Drd4 NM_007878 P51436
Rat Drd4 NM_012944 P30729